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Tlr9 toll-like receptor 9 [ Mus musculus (house mouse) ]

Gene ID: 81897, updated on 15-Sep-2014
Official Symbol
Tlr9provided by MGI
Official Full Name
toll-like receptor 9provided by MGI
Primary source
MGI:1932389
See related
Ensembl:ENSMUSG00000045322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
See Tlr9 in Epigenomics, MapViewer
Location:
9 F1; 9
Exon count:
2
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 9 NC_000075.6 (106222598..106226876)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1M Neighboring gene twinfilin, actin-binding protein, homolog 2 (Drosophila) Neighboring gene aminolevulinic acid synthase 1 Neighboring gene uncharacterized LOC102636338

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
interleukin-1 receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
siRNA binding ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
unmethylated CpG binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
I-kappaB phosphorylation ISO
Inferred from Sequence Orthology
more info
 
MyD88-dependent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
defense response to virus IGI
Inferred from Genetic Interaction
more info
PubMed 
defense response to virus ISO
Inferred from Sequence Orthology
more info
 
immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response TAS
Traceable Author Statement
more info
PubMed 
maintenance of gastrointestinal epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-alpha biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-beta biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-gamma biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-10 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-18 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of B cell activation IGI
Inferred from Genetic Interaction
more info
 
regulation of cytokine secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to molecule of bacterial origin TAS
Traceable Author Statement
more info
PubMed 
response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor 9 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
early phagosome IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Preferred Names
toll-like receptor 9
Names
toll-like receptor 9

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031178.2NP_112455.2  toll-like receptor 9 precursor

    See proteins identical to NP_112455.2

    Status: VALIDATED

    Source sequence(s)
    AC164430
    Consensus CDS
    CCDS40755.1
    UniProtKB/Swiss-Prot
    Q9EQU3
    Related
    ENSMUSP00000082207, ENSMUST00000062241
    Conserved Domains (3) summary
    cd00116
    Location:194373
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam13855
    Location:497557
    LRR_8; Leucine rich repeat
    cl17458
    Location:8721012
    TIR_2; TIR domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000075.6 

    Range
    106222598..106226876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000031.1 

    Range
    105848890..105853167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)