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    Apoe apolipoprotein E [ Mus musculus (house mouse) ]

    Gene ID: 11816, updated on 26-Jun-2016
    Official Symbol
    Apoeprovided by MGI
    Official Full Name
    apolipoprotein Eprovided by MGI
    Primary source
    MGI:MGI:88057
    See related
    Ensembl:ENSMUSG00000002985 Vega:OTTMUSG00000038239
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apo-E; AI255918
    Summary
    This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related apolipoprotein C1, C2 and C4 genes. [provided by RefSeq, Apr 2015]
    Orthologs
    Location:
    7 A3; 7 9.94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (19696244..19699188, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (20281593..20284515, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene Apoc4-Apoc2 readthrough Neighboring gene apolipoprotein C-IV Neighboring gene apolipoprotein C-I Neighboring gene translocase of outer mitochondrial membrane 40 homolog (yeast) Neighboring gene predicted gene, 38955 Neighboring gene nectin cell adhesion molecule 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    antioxidant activity ISO
    Inferred from Sequence Orthology
    more info
     
    beta-amyloid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    beta-amyloid binding ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cholesterol transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydroxyapatite binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    low-density lipoprotein particle receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal chelating activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylcholine-sterol O-acyltransferase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphatidylcholine-sterol O-acyltransferase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    very-low-density lipoprotein particle receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    very-low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    AMPA glutamate receptor clustering ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    NMDA glutamate receptor clustering ISO
    Inferred from Sequence Orthology
    more info
     
    aging ISO
    Inferred from Sequence Orthology
    more info
     
    artery morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT axon regeneration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cardiovascular system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cholesterol catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    chylomicron remnant clearance ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    high-density lipoprotein particle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    high-density lipoprotein particle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    high-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
     
    high-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    lipoprotein biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lipoprotein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipoprotein metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lipoprotein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    long-chain fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    low-density lipoprotein particle remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of location in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of beta-amyloid formation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of dendritic spine maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipid transport across blood brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of phospholipid efflux ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of postsynaptic membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of presynaptic membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    nitric oxide mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid efflux IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phospholipid efflux ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation by host of viral process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of beta-amyloid formation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cGMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol esterification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cholesterol esterification ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic spine maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lipid transport across blood brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of low-density lipoprotein particle receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurofibrillary tangle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric-oxide synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phospholipid efflux ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of postsynaptic membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of presynaptic membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    protein import ISO
    Inferred from Sequence Orthology
    more info
     
    NOT protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Cdc42 protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of axon extension IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of beta-amyloid clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of beta-amyloid clearance ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of tau-protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to dietary excess IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    reverse cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    reverse cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    very-low-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
     
    very-low-density lipoprotein particle remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    very-low-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    virion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    blood microparticle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    blood microparticle ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    chylomicron IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chylomicron ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    discoidal high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    high-density lipoprotein particle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    intermediate-density lipoprotein particle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intermediate-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    low-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    very-low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305819.1NP_001292748.1  apolipoprotein E precursor

      See identical proteins and their annotated locations for NP_001292748.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
      Source sequence(s)
      AI836733, AK134921, DN173921
      UniProtKB/Swiss-Prot
      P08226
      UniProtKB/TrEMBL
      Q3TXU4
      Related
      ENSMUSP00000133371, OTTMUSP00000055346, ENSMUST00000173739, OTTMUST00000098458
      Conserved Domains (3) summary
      pfam01442
      Location:96291
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam02720
      Location:106244
      DUF222; Domain of unknown function (DUF222)
      cl03075
      Location:55124
      GrpE; nucleotide exchange factor GrpE
    2. NM_001305843.1NP_001292772.1  apolipoprotein E precursor

      See identical proteins and their annotated locations for NP_001292772.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC149282, AI836733, AK134921, BY313639, BY772289
      UniProtKB/Swiss-Prot
      P08226
      UniProtKB/TrEMBL
      Q3TXU4
      Conserved Domains (3) summary
      pfam01442
      Location:96291
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam02720
      Location:106244
      DUF222; Domain of unknown function (DUF222)
      cl03075
      Location:55124
      GrpE; nucleotide exchange factor GrpE
    3. NM_001305844.1NP_001292773.1  apolipoprotein E precursor

      See identical proteins and their annotated locations for NP_001292773.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC149282, AI836733, AK134921
      UniProtKB/Swiss-Prot
      P08226
      UniProtKB/TrEMBL
      Q3TXU4
      Conserved Domains (3) summary
      pfam01442
      Location:96291
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam02720
      Location:106244
      DUF222; Domain of unknown function (DUF222)
      cl03075
      Location:55124
      GrpE; nucleotide exchange factor GrpE
    4. NM_009696.4NP_033826.2  apolipoprotein E precursor

      See identical proteins and their annotated locations for NP_033826.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
      Source sequence(s)
      AI836733, AK134921, BY313639, BY772289
      Consensus CDS
      CCDS20912.1
      UniProtKB/Swiss-Prot
      P08226
      UniProtKB/TrEMBL
      Q3TXU4
      Related
      ENSMUSP00000133302, OTTMUSP00000055344, ENSMUST00000174064, OTTMUST00000098456
      Conserved Domains (3) summary
      pfam01442
      Location:96291
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam02720
      Location:106244
      DUF222; Domain of unknown function (DUF222)
      cl03075
      Location:55124
      GrpE; nucleotide exchange factor GrpE

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      19696244..19699188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)