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IFNL3 interferon, lambda 3 [ Homo sapiens (human) ]

Gene ID: 282617, updated on 13-Jul-2014
Official Symbol
IFNL3provided by HGNC
Official Full Name
interferon, lambda 3provided by HGNC
Primary source
HGNC:18365
See related
Ensembl:ENSG00000197110; HPRD:09587; MIM:607402; Vega:OTTHUMG00000182805
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL28B; IL28C; IL-28B
Summary
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
See IFNL3 in Epigenomics, MapViewer
Location:
19q13.13
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (39243632..39245077, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39734272..39735916, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene syncollin Neighboring gene interferon, lambda 3 pseudogene 1 Neighboring gene interferon, lambda 4 (gene/pseudogene) Neighboring gene methionine sulfoxide reductase B1 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Hepatitis c virus, susceptibility to
MedGen: C1835407 OMIM: 609532 GeneReviews: Not available
Compare labs
Peginterferon alfa-2a response
MedGen: CN184128 GeneReviews: Not available
not available
Peginterferon alfa-2b response
MedGen: CN078000 GeneReviews: Not available
not available
Ribavirin response
MedGen: CN184129 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.
NHGRI GWA Catalog
Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.
NHGRI GWA Catalog
Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts.
NHGRI GWA Catalog
IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy.
NHGRI GWA Catalog
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Type III interferon signaling, organism-specific biosystem (from WikiPathways)
    Type III interferon signaling, organism-specific biosystemThe recently identified type III interferon group consists of three IFN-? (lambda) genes encoding molecules called IFN-?1, IFN-?2 and IFN-?3 (also called IL29, IL28A and IL28B respectively). These IF...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
JAK-STAT cascade IEA
Inferred from Electronic Annotation
more info
 
defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of viral genome replication ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
interferon lambda-3
Names
interferon lambda-3
IL-28C
IFN-lambda-3
IFN-lambda-4
interleukin 28C
interleukin-28B
interleukin-28C
cytokine Zcyto22
interferon lambda-4
interferon, lambda 4
interleukin 28B (interferon, lambda 3)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172139.2NP_742151.2  interferon lambda-3 precursor

    See proteins identical to NP_742151.2

    Status: REVIEWED

    Source sequence(s)
    AY129149
    Consensus CDS
    CCDS12530.1
    UniProtKB/Swiss-Prot
    Q8IZI9
    Related
    ENSP00000409000, OTTHUMP00000270255, ENST00000413851, OTTHUMT00000463832

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    39243632..39245077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258765.2XP_005258822.1  

    See proteins identical to XP_005258822.1

    UniProtKB/Swiss-Prot
    Q8IZI9
    Conserved Domains (1) summary
    pfam15177
    Location:36197
    Blast Score: 761
    IL28A; Interleukin-28A

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    36181319..36182658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    39735081..39736420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)