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TRPV1 transient receptor potential cation channel, subfamily V, member 1 [ Homo sapiens (human) ]

Gene ID: 7442, updated on 7-Dec-2014
Official Symbol
TRPV1provided by HGNC
Official Full Name
transient receptor potential cation channel, subfamily V, member 1provided by HGNC
Primary source
HGNC:HGNC:12716
See related
Ensembl:ENSG00000196689; Ensembl:ENSG00000262304; HPRD:03648; MIM:602076; Vega:OTTHUMG00000177649; Vega:OTTHUMG00000177650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VR1
Summary
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
See TRPV1 in Epigenomics, MapViewer
Location:
17p13.2
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (3565446..3609411, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3468740..3512705, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 22 Neighboring gene aspartoacylase Neighboring gene transient receptor potential cation channel, subfamily V, member 3 Neighboring gene pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 pseudogene Neighboring gene sedoheptulokinase Neighboring gene P2RX5-TAX1BP3 readthrough (NMD candidate) Neighboring gene cystinosin, lysosomal cystine transporter Neighboring gene Tax1 (human T-cell leukemia virus type I) binding protein 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp434K0220

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium channel activity TAS
Traceable Author Statement
more info
PubMed 
calcium-release channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
excitatory extracellular ligand-gated ion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
calcium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cellular response to ATP ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to alkaloid ISS
Inferred from Sequence or Structural Similarity
more info
 
chemosensory behavior TAS
Traceable Author Statement
more info
PubMed 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
thermoception IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane transport TAS
Traceable Author Statement
more info
 
transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendritic spine membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intrinsic component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
transient receptor potential cation channel subfamily V member 1
Names
transient receptor potential cation channel subfamily V member 1
OTRPC1
capsaicin receptor
osm-9-like TRP channel 1
vanilloid receptor subtype 1
transient receptor potential vanilloid 1a
transient receptor potential vanilloid 1b

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029716.1 

    Range
    5001..48966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018727.5NP_061197.4  transient receptor potential cation channel subfamily V member 1

    See proteins identical to NP_061197.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a different segment in the 5' UTR, compared to variant 3. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC027796, AF196175, AJ272063, AL136801
    Consensus CDS
    CCDS45576.1
    UniProtKB/Swiss-Prot
    Q8NER1
    Related
    ENSP00000461007, OTTHUMP00000257339, ENST00000571088, OTTHUMT00000438254
    Conserved Domains (2) summary
    TIGR00870
    Location:52825
    trp; transient-receptor-potential calcium channel protein
    cd00204
    Location:200354
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
  2. NM_080704.3NP_542435.2  transient receptor potential cation channel subfamily V member 1

    See proteins identical to NP_542435.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains a different segment in the 5' UTR, compared to variant 3. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC027796, AF196175, AJ272063, AL136801
    Consensus CDS
    CCDS45576.1
    UniProtKB/Swiss-Prot
    Q8NER1
    Related
    ENSP00000459962, OTTHUMP00000257344, ENST00000572705, OTTHUMT00000438261
    Conserved Domains (2) summary
    TIGR00870
    Location:52825
    trp; transient-receptor-potential calcium channel protein
    cd00204
    Location:200354
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
  3. NM_080705.3NP_542436.2  transient receptor potential cation channel subfamily V member 1

    See proteins identical to NP_542436.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a different segment in the 5' UTR, compared to variant 3. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC027796, AF196175, AJ272063, AL136801
    Consensus CDS
    CCDS45576.1
    UniProtKB/Swiss-Prot
    Q8NER1
    Related
    ENSP00000382661, OTTHUMP00000257338, ENST00000399759, OTTHUMT00000438253
    Conserved Domains (2) summary
    TIGR00870
    Location:52825
    trp; transient-receptor-potential calcium channel protein
    cd00204
    Location:200354
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
  4. NM_080706.3NP_542437.2  transient receptor potential cation channel subfamily V member 1

    See proteins identical to NP_542437.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC027796, AF196175, AJ272063, AJ277028, AL136801
    Consensus CDS
    CCDS45576.1
    UniProtKB/Swiss-Prot
    Q8NER1
    Related
    ENSP00000382659, OTTHUMP00000257340, ENST00000399756, OTTHUMT00000438255
    Conserved Domains (2) summary
    TIGR00870
    Location:52825
    trp; transient-receptor-potential calcium channel protein
    cd00204
    Location:200354
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    3565446..3609411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    3479568..3523488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    3360449..3404458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)