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    Efemp2 epidermal growth factor-containing fibulin-like extracellular matrix protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 58859, updated on 15-Dec-2015
    Official Symbol
    Efemp2provided by MGI
    Official Full Name
    epidermal growth factor-containing fibulin-like extracellular matrix protein 2provided by MGI
    Primary source
    MGI:MGI:1891209
    See related
    Ensembl:ENSMUSG00000024909; Vega:OTTMUSG00000036759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MBP1; Fbln4; 0610011K11Rik
    Orthologs
    See Efemp2 in Epigenomics, MapViewer
    Location:
    19; 19 A
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (5473960..5481854)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (5474690..5481854)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor (acidic) intracellular binding protein Neighboring gene cathepsin W Neighboring gene MUS81 endonuclease homolog (yeast) Neighboring gene cofilin 1, non-muscle

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    proteinaceous extracellular matrix TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    EGF-containing fibulin-like extracellular matrix protein 2
    Names
    EGF-containing fibulin-like extracellular matrix protein 2 (Efemp2)
    FIBL-4
    fibulin 4
    fibulin-4
    mutant p53-binding protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164352.1NP_001157824.1  EGF-containing fibulin-like extracellular matrix protein 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001157824.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) retains a segment in its 5' end which results in the use of an upstream start codon, compared to variant 1. The resulting protein (isoform 2) has a longer N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AI327154, AK075585, CJ093169
      Consensus CDS
      CCDS50358.1
      UniProtKB/TrEMBL
      G5E8D6
      UniProtKB/TrEMBL
      Q542X5
      Related
      ENSMUSP00000064719, OTTMUSP00000052424, ENSMUST00000070118, OTTMUST00000094317
      Conserved Domains (4) summary
      smart00179
      Location:183216
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:142182
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl00057
      Location:217257
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl21504
      Location:302329
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    2. NM_021474.3NP_067449.3  EGF-containing fibulin-like extracellular matrix protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_067449.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the more frequently occurring transcript.
      Source sequence(s)
      AI327154, AK075585, BY234446
      Consensus CDS
      CCDS29466.1
      UniProtKB/TrEMBL
      Q542X5
      UniProtKB/Swiss-Prot
      Q9WVJ9
      Related
      ENSMUSP00000133016, OTTMUSP00000052420, ENSMUST00000165485, OTTMUST00000094312
      Conserved Domains (4) summary
      smart00179
      Location:164197
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:123163
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl00057
      Location:198238
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl21504
      Location:283310
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

      Range
      5473960..5481854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531807.1XP_006531870.1  

      Conserved Domains (4) summary
      smart00179
      Location:166199
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:125165
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl00057
      Location:200240
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl21504
      Location:285312
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    2. XM_006531808.1XP_006531871.1  

      See identical proteins and their annotated locations for XP_006531871.1

      UniProtKB/TrEMBL
      Q542X5
      UniProtKB/Swiss-Prot
      Q9WVJ9
      Conserved Domains (4) summary
      smart00179
      Location:164197
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:123163
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl00057
      Location:198238
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl21504
      Location:283310
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    3. XM_006531809.1XP_006531872.1  

      Conserved Domains (4) summary
      smart00179
      Location:142175
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:101141
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl00057
      Location:176216
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl21504
      Location:261288
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    4. XM_006531811.2XP_006531874.1  

      Conserved Domains (3) summary
      cd00054
      Location:142182
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam12662
      Location:202225
      cEGF; Complement Clr-like EGF-like
      cl00057
      Location:217257
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    5. XM_006531810.2XP_006531873.1  

      Conserved Domains (4) summary
      smart00179
      Location:96129
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:5595
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl00057
      Location:130170
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl21504
      Location:215242
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    Alternate Mm_Celera

    Genomic

    1. AC_000041.1 Alternate Mm_Celera

      Range
      5346431..5353554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)