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Cxcr4 chemokine (C-X-C motif) receptor 4 [ Mus musculus (house mouse) ]

Gene ID: 12767, updated on 18-Jan-2015
Official Symbol
Cxcr4provided by MGI
Official Full Name
chemokine (C-X-C motif) receptor 4provided by MGI
Primary source
MGI:MGI:109563
See related
Ensembl:ENSMUSG00000045382; Vega:OTTMUSG00000020918
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD184; LESTR; Sdf1r; Cmkar4; PB-CKR; b2b220Clo; PBSF/SDF-1
Orthologs
See Cxcr4 in MapViewer
Location:
1 E4; 1 56.43 cM
Exon count:
3
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 1 NC_000067.6 (128588199..128592313, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene aspartyl-tRNA synthetase Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene thrombospondin, type I, domain containing 7B Neighboring gene predicted gene, 36347 Neighboring gene nucleoporin 54 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Chemically induced (ENU) (1) 

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
C-X-C chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
actin binding ISO
Inferred from Sequence Orthology
more info
 
chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
cytokine binding IEA
Inferred from Electronic Annotation
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
myosin light chain binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ameboidal-type cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
chemokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
epithelial cell development ISO
Inferred from Sequence Orthology
more info
 
germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
myelin maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
neuron migration IDA
Inferred from Direct Assay
more info
PubMed 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
neutrophil activation IEA
Inferred from Electronic Annotation
more info
 
organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
patterning of blood vessels IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
telencephalon cell migration ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell leading edge ISO
Inferred from Sequence Orthology
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic membrane-bounded vesicle ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome ISO
Inferred from Sequence Orthology
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
C-X-C chemokine receptor type 4
Names
C-X-C chemokine receptor type 4
fusin
CXC-R4
CXCR-4
SDF-1 receptor
chemokine receptor 4
chemokine (C-X-C) receptor 4
pre-B-cell-derived chemokine receptor
stromal cell-derived factor 1 receptor
leukocyte-expressed seven-transmembrane-domain
leukocyte-derived seven transmembrane domain receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009911.3NP_034041.2  C-X-C chemokine receptor type 4

    See proteins identical to NP_034041.2

    Status: VALIDATED

    Source sequence(s)
    AB000803, BB872868, BF662224
    Consensus CDS
    CCDS15254.1
    UniProtKB/Swiss-Prot
    P70658
    Related
    ENSMUSP00000053489, OTTMUSP00000022912, ENSMUST00000052172, OTTMUST00000049443
    Conserved Domains (2) summary
    pfam12109
    Location:840
    CXCR4_N; CXCR4 Chemokine receptor N terminal
    pfam00001
    Location:63309
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000067.6 

    Range
    128588199..128592313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529113.1XP_006529176.1  

    Conserved Domains (2) summary
    pfam12109
    Location:638
    CXCR4_N; CXCR4 Chemokine receptor N terminal
    pfam00001
    Location:61307
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_006529114.1XP_006529177.1  

    Conserved Domains (2) summary
    pfam12109
    Location:537
    CXCR4_N; CXCR4 Chemokine receptor N terminal
    pfam00001
    Location:60306
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate Mm_Celera

Genomic

  1. AC_000023.1 

    Range
    131222729..131226820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)