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IL13RA2 interleukin 13 receptor, alpha 2 [ Homo sapiens (human) ]

Gene ID: 3598, updated on 13-Jan-2015
Official Symbol
IL13RA2provided by HGNC
Official Full Name
interleukin 13 receptor, alpha 2provided by HGNC
Primary source
HGNC:HGNC:5975
See related
Ensembl:ENSG00000123496; HPRD:02132; MIM:300130; Vega:OTTHUMG00000022229
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT19; IL-13R; IL13BP; CD213A2
Summary
The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]
Orthologs
See IL13RA2 in MapViewer
Location:
Xq23
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) X NC_000023.11 (115003975..115017644, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (114238538..114252207, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Neighboring gene heat shock 70kDa protein 8 pseudogene 7 Neighboring gene microRNA 448 Neighboring gene zinc finger protein 670 pseudogene Neighboring gene Yes-associated protein 1 pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL4-mediated signaling events, organism-specific biosystem
    IL4-mediated signaling events
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine receptor activity TAS
Traceable Author Statement
more info
PubMed 
signal transducer activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular space TAS
Traceable Author Statement
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
interleukin-13 receptor subunit alpha-2
Names
interleukin-13 receptor subunit alpha-2
IL-13RA2
IL-13R-alpha-2
IL-13R subunit alpha-2
cancer/testis antigen 19
IL-13 receptor subunit alpha-2
interleukin 13 binding protein
interleukin-13-binding protein
interleukin 13 receptor alpha 2 chain

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012514.1 

    Range
    5001..18670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000640.2NP_000631.1  interleukin-13 receptor subunit alpha-2 precursor

    See proteins identical to NP_000631.1

    Status: REVIEWED

    Source sequence(s)
    Y08768
    Consensus CDS
    CCDS14565.1
    UniProtKB/Swiss-Prot
    Q14627
    Related
    ENSP00000243213, ENST00000243213
    Conserved Domains (1) summary
    pfam09240
    Location:139235
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000023.11 

    Range
    115003975..115017644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 

    Range
    114149412..114163077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000155.1 

    Range
    103824475..103837544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)