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    Tdgf1 teratocarcinoma-derived growth factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 21667, updated on 4-Sep-2016
    Official Symbol
    Tdgf1provided by MGI
    Official Full Name
    teratocarcinoma-derived growth factor 1provided by MGI
    Primary source
    MGI:MGI:98658
    See related
    Ensembl:ENSMUSG00000032494 Vega:OTTMUSG00000052499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CR1; cripto
    Orthologs
    Location:
    9 F3; 9 60.79 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (110939608..110946158, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (110842112..110848662, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene ALS2 C-terminal like Neighboring gene predicted gene 590 Neighboring gene leucine rich repeat containing 2 Neighboring gene predicted gene 10030 Neighboring gene receptor transporter protein 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    coreceptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nodal binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    type I activin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    anterior/posterior axis specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    anterior/posterior axis specification, embryo IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to fibroblast growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hepatocyte growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interleukin-6 ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    NOT epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    gastrulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    heart development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    morphogenesis of a branching structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    nodal signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    nodal signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    teratocarcinoma-derived growth factor
    Names
    TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR)
    cripto growth factor
    epidermal growth factor-like Cripto protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011562.2NP_035692.2  teratocarcinoma-derived growth factor precursor

      See identical proteins and their annotated locations for NP_035692.2

      Status: VALIDATED

      Source sequence(s)
      AK133730, BC052646, CJ074826
      Consensus CDS
      CCDS40783.1
      UniProtKB/TrEMBL
      Q3UZP8, Q7TQ06
      Related
      ENSMUSP00000035075, OTTMUSP00000070340, ENSMUST00000035075, OTTMUST00000131653
      Conserved Domains (2) summary
      cd00054
      Location:6791
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam09443
      Location:99133
      CFC; Cripto_Frl-1_Cryptic (CFC)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      110939608..110946158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313275.1XP_017168764.1  

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