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    Chek2 checkpoint kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 50883, updated on 3-Apr-2016
    Official Symbol
    Chek2provided by MGI
    Official Full Name
    checkpoint kinase 2provided by MGI
    Primary source
    MGI:MGI:1355321
    See related
    Ensembl:ENSMUSG00000029521 Vega:OTTMUSG00000054224
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CHK2; Cds1; Rad53; HUCDS1
    Orthologs
    Location:
    5; 5 F
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (110839791..110874140)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (111269036..111303152)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 26515 Neighboring gene pseudouridine synthase 1 Neighboring gene unc-51 like kinase 1 Neighboring gene HscB iron-sulfur cluster co-chaperone Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene predicted gene, 35973 Neighboring gene predicted gene, 42153

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

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    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle signaling pathway, organism-specific biosystem (from LIPID MAPS)
      Cell cycle signaling pathway, organism-specific biosystem
      Cell cycle signaling pathway
    • DNA damage-induced cell cycle checkpoints, organism-specific biosystem (from KEGG)
      DNA damage-induced cell cycle checkpoints, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • DNA damage-induced cell cycle checkpoints, conserved biosystem (from KEGG)
      DNA damage-induced cell cycle checkpoints, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • miRNA regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
      miRNA regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    DNA damage induced protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    replicative cell aging ISO
    Inferred from Sequence Orthology
    more info
     
    response to gamma radiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction involved in intra-S DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    PML body ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    serine/threonine-protein kinase Chk2
    Names
    CHK2 checkpoint homolog
    Cds1 homolog
    Rad53 homolog
    protein kinase Chk2
    NP_057890.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016681.3NP_057890.1  serine/threonine-protein kinase Chk2

      See identical proteins and their annotated locations for NP_057890.1

      Status: PROVISIONAL

      Source sequence(s)
      AK044913
      Consensus CDS
      CCDS19533.1
      UniProtKB/Swiss-Prot
      Q9Z265
      UniProtKB/TrEMBL
      Q543W6
      Related
      ENSMUSP00000066679, OTTMUSP00000071369, ENSMUST00000066160, OTTMUST00000134619
      Conserved Domains (3) summary
      smart00220
      Location:224490
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00060
      Location:97205
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:217490
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

      Range
      110839791..110874140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535071.2XP_006535134.1  

      Conserved Domains (3) summary
      smart00220
      Location:284484
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00060
      Location:157265
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl21453
      Location:277484
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006535072.2XP_006535135.1  

      Conserved Domains (3) summary
      smart00220
      Location:284484
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00060
      Location:157265
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl21453
      Location:277484
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006535068.2XP_006535131.1  

      Conserved Domains (3) summary
      smart00220
      Location:284550
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00060
      Location:157265
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:277550
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
    4. XM_006535067.2XP_006535130.1  

      Conserved Domains (3) summary
      smart00220
      Location:284550
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00060
      Location:157265
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:277550
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
    5. XM_006535069.2XP_006535132.1  

      See identical proteins and their annotated locations for XP_006535132.1

      UniProtKB/Swiss-Prot
      Q9Z265
      UniProtKB/TrEMBL
      Q543W6
      Conserved Domains (3) summary
      smart00220
      Location:224490
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00060
      Location:97205
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:217490
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
    6. XM_006535070.2XP_006535133.1  

      See identical proteins and their annotated locations for XP_006535133.1

      UniProtKB/Swiss-Prot
      Q9Z265
      UniProtKB/TrEMBL
      Q543W6
      Conserved Domains (3) summary
      smart00220
      Location:224490
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00060
      Location:97205
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:217490
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
    7. XM_011249509.1XP_011247811.1  

      Conserved Domains (2) summary
      smart00220
      Location:2251
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14084
      Location:1251
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    RNA

    1. XR_880398.1 RNA Sequence

      Related
      ENSMUST00000199937, OTTMUST00000134618

    Alternate Mm_Celera

    Genomic

    1. AC_000027.1 Alternate Mm_Celera

      Range
      107972108..108006794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)