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Creb1 cAMP responsive element binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 12912, updated on 7-Apr-2015
Official Symbol
Creb1provided by MGI
Official Full Name
cAMP responsive element binding protein 1provided by MGI
Primary source
MGI:MGI:88494
See related
Ensembl:ENSMUSG00000025958; Vega:OTTMUSG00000047617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Creb; Creb-1; AV083133; 2310001E10Rik; 3526402H21Rik
Orthologs
See Creb1 in MapViewer
Location:
1 C2; 1 32.74 cM
Exon count:
12
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (64532804..64604548)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (64579378..64651122)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene 28980 Neighboring gene predicted gene, 36148 Neighboring gene methyltransferase like 21A Neighboring gene predicted gene 29152

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription ISO
Inferred from Sequence Orthology
more info
 
cAMP response element binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Type I pneumocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung epithelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung saccule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by competitive promoter binding ISO
Inferred from Sequence Orthology
more info
 
pituitary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of lipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription, DNA-templated IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transforming growth factor beta3 production ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of cell size IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to glucagon IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to organic substance ISO
Inferred from Sequence Orthology
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
secretory granule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
ATF4-CREB1 transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
ATF4-CREB1 transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
chromatin ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear euchromatin ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cyclic AMP-responsive element-binding protein 1
Names
cyclic AMP-responsive element-binding protein 1
cAMP-responsive element-binding protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037726.1NP_001032815.1  cyclic AMP-responsive element-binding protein 1 isoform C

    See identical proteins and their annotated locations for NP_001032815.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant A. The encoded protein (isoform C) has a shorter N-terminus, compared to isoform A.
    Source sequence(s)
    AC166336, AK044992, BY315899, CD776417
    Consensus CDS
    CCDS48280.1
    UniProtKB/TrEMBL
    Q543W0
    UniProtKB/TrEMBL
    Q62347
    Conserved Domains (2) summary
    pfam02173
    Location:5997
    pKID; pKID domain
    cd14690
    Location:231285
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  2. NM_009952.2NP_034082.1  cyclic AMP-responsive element-binding protein 1 isoform B

    See identical proteins and their annotated locations for NP_034082.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) includes an alternate in-frame exon in the 5' coding region, compared to variant A, resulting in a longer protein (isoform B), compared to isoform A.
    Source sequence(s)
    AC124361, BB831364, BY315899, CD776417, M95106
    Consensus CDS
    CCDS15004.1
    UniProtKB/Swiss-Prot
    Q01147
    UniProtKB/TrEMBL
    Q547S9
    Conserved Domains (2) summary
    pfam02173
    Location:113151
    pKID; pKID domain
    cd12193
    Location:285337
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  3. NM_133828.2NP_598589.2  cyclic AMP-responsive element-binding protein 1 isoform A

    See identical proteins and their annotated locations for NP_598589.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) encodes isoform A.
    Source sequence(s)
    AC124361, AK044992, BY315899, BY782293, CD776417
    Consensus CDS
    CCDS15005.1
    UniProtKB/Swiss-Prot
    Q01147
    UniProtKB/TrEMBL
    Q543W0
    Related
    ENSMUSP00000084624, OTTMUSP00000067238, ENSMUST00000087366, OTTMUST00000122767
    Conserved Domains (2) summary
    pfam02173
    Location:99137
    pKID; pKID domain
    cd12193
    Location:271323
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    64532804..64604548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495650.2XP_006495713.1  

    See identical proteins and their annotated locations for XP_006495713.1

    UniProtKB/Swiss-Prot
    Q01147
    UniProtKB/TrEMBL
    Q547S9
    Conserved Domains (2) summary
    pfam02173
    Location:113151
    pKID; pKID domain
    cd12193
    Location:285337
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  2. XM_006495651.2XP_006495714.1  

    See identical proteins and their annotated locations for XP_006495714.1

    UniProtKB/Swiss-Prot
    Q01147
    UniProtKB/TrEMBL
    Q543W0
    Conserved Domains (2) summary
    pfam02173
    Location:99137
    pKID; pKID domain
    cd12193
    Location:271323
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  3. XM_006495653.2XP_006495716.1  

    Conserved Domains (2) summary
    pfam02173
    Location:113151
    pKID; pKID domain
    cd12193
    Location:224276
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  4. XM_006495654.2XP_006495717.1  

    Conserved Domains (2) summary
    pfam02173
    Location:99137
    pKID; pKID domain
    cd12193
    Location:210262
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  5. XM_006495652.2XP_006495715.1  

    See identical proteins and their annotated locations for XP_006495715.1

    Conserved Domains (2) summary
    pfam02173
    Location:73111
    pKID; pKID domain
    cd14690
    Location:245299
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  6. XM_011238424.1XP_011236726.1  

    See identical proteins and their annotated locations for XP_011236726.1

    Conserved Domains (1) summary
    cd14690
    Location:77131
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  7. XM_011238425.1XP_011236727.1  

    See identical proteins and their annotated locations for XP_011236727.1

    Conserved Domains (1) summary
    cd14690
    Location:77131
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  8. XM_006495655.2XP_006495718.1  

    Conserved Domains (1) summary
    cd12193
    Location:55107
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    65034311..65105954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)