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AAK1 AP2 associated kinase 1 [ Homo sapiens (human) ]

Gene ID: 22848, updated on 17-Feb-2015
Official Symbol
AAK1provided by HGNC
Official Full Name
AP2 associated kinase 1provided by HGNC
Primary source
HGNC:HGNC:19679
See related
Ensembl:ENSG00000115977; HPRD:10620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Orthologs
See AAK1 in MapViewer
Location:
2p14
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (69457995..69643845, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (69685127..69901566, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene glutamine--fructose-6-phosphate transaminase 1 Neighboring gene NFU1 iron-sulfur cluster scaffold Neighboring gene small nucleolar RNA, H/ACA box 36C Neighboring gene beta-1,3-N-acetylgalactosaminyltransferase 1 pseudogene 1 Neighboring gene ribosomal protein L36a pseudogene 16 Neighboring gene annexin A4 Neighboring gene germ cell-less, spermatogenesis associated 1

NHGRI GWAS Catalog

Description
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
NHGRI GWA Catalog
Genomewide association study for onset age in Parkinson disease.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of AP2 associated kinase 1 (AAK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ23712, FLJ25931, FLJ31060, FLJ42882, FLJ45252, KIAA1048, MGC138170, MGC164568, MGC164570, DKFZp686F03202, DKFZp686K16132

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AP-2 adaptor complex binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Notch binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
endocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of clathrin-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of clathrin-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell leading edge ISS
Inferred from Sequence or Structural Similarity
more info
 
clathrin-coated vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
coated pit IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
terminal bouton ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
AP2-associated protein kinase 1
Names
AP2-associated protein kinase 1
adaptor-associated kinase 1
NP_055726.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014911.3NP_055726.3  AP2-associated protein kinase 1

    Status: REVIEWED

    Source sequence(s)
    AC114772, AC136007, AW451954, AW969393, BC111965, CA436375, DA121999, DB285703
    Consensus CDS
    CCDS1893.2
    UniProtKB/Swiss-Prot
    Q2M2I8
    Related
    ENSP00000478720, ENST00000339092
    Conserved Domains (2) summary
    smart00220
    Location:47307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:42316
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38 Primary Assembly

    Range
    69457995..69643845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    69614737..69800612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000134.1 Alternate HuRef

    Range
    69421353..69607695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)