Display Settings:

Format

Send to:

Choose Destination

Ctsb cathepsin B [ Mus musculus (house mouse) ]

Gene ID: 13030, updated on 13-Jan-2015
Official Symbol
Ctsbprovided by MGI
Official Full Name
cathepsin Bprovided by MGI
Primary source
MGI:MGI:88561
See related
Ensembl:ENSMUSG00000021939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CB
Orthologs
See Ctsb in MapViewer
Location:
14 D1; 14 33.24 cM
Exon count:
10
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 14 NC_000080.6 (63122462..63145923)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35965 Neighboring gene predicted gene, 36025 Neighboring gene tubulin, alpha 3B pseudogene Neighboring gene farnesyl diphosphate farnesyl transferase 1 Neighboring gene nei like 2 (E. coli) Neighboring gene GATA binding protein 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
collagen binding ISO
Inferred from Sequence Orthology
more info
 
cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
kininogen binding ISO
Inferred from Sequence Orthology
more info
 
peptidase activity ISO
Inferred from Sequence Orthology
more info
 
peptide binding ISO
Inferred from Sequence Orthology
more info
 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein self-association ISO
Inferred from Sequence Orthology
more info
 
proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
collagen catabolic process ISO
Inferred from Sequence Orthology
more info
 
decidualization IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
proteolysis involved in cellular protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with caveola ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosome ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cathepsin B
Names
cathepsin B
cathepsin B1
NP_031824.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007798.3NP_031824.1  cathepsin B preproprotein

    See proteins identical to NP_031824.1

    Status: VALIDATED

    Source sequence(s)
    AC090654, AK083393, AK151790, BI733634
    Consensus CDS
    CCDS27197.1
    UniProtKB/Swiss-Prot
    P10605
    Related
    ENSMUSP00000006235, ENSMUST00000006235
    Conserved Domains (2) summary
    pfam08127
    Location:2666
    Propeptide_C1; Peptidase family C1 propeptide
    cd02620
    Location:81328
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000080.6 

    Range
    63122462..63145923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000036.1 

    Range
    60885227..60908695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)