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Itgb6 integrin beta 6 [ Mus musculus (house mouse) ]

Gene ID: 16420, updated on 5-May-2015
Official Symbol
Itgb6provided by MGI
Official Full Name
integrin beta 6provided by MGI
Primary source
MGI:MGI:96615
See related
Ensembl:ENSMUSG00000026971; Vega:OTTMUSG00000012790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2210409C20Rik; 4831415H04Rik
Orthologs
See Itgb6 in MapViewer
Location:
2 34.81 cM; 2 C3
Exon count:
21
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (60598292..60722603, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (60436349..60560660, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S21 pseudogene Neighboring gene TBC1 domain family, member 15 pseudogene Neighboring gene predicted gene, 33436 Neighboring gene RNA binding motif, single stranded interacting protein 1 Neighboring gene predicted gene, 33598 Neighboring gene predicted gene 13582 Neighboring gene predicted gene, 33647

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • ECM proteoglycans, organism-specific biosystem (from REACTOME)
    ECM proteoglycans, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • ECM-receptor interaction, organism-specific biosystem (from KEGG)
    ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • ECM-receptor interaction, conserved biosystem (from KEGG)
    ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • Elastic fibre formation, organism-specific biosystem (from REACTOME)
    Elastic fibre formation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
    Integrin cell surface interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
  • Molecules associated with elastic fibres, organism-specific biosystem (from REACTOME)
    Molecules associated with elastic fibres, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integrin complex IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
integrin beta-6
Names
integrin beta-6

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159564.1NP_001153036.1  integrin beta-6 precursor

    See identical proteins and their annotated locations for NP_001153036.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AK036439, AL928546
    Consensus CDS
    CCDS16060.1
    UniProtKB/Swiss-Prot
    Q9Z0T9
    Conserved Domains (3) summary
    pfam08725
    Location:730775
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam00362
    Location:30454
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:624706
    Integrin_B_tail; Integrin beta tail domain
  2. NM_021359.3NP_067334.1  integrin beta-6 precursor

    See identical proteins and their annotated locations for NP_067334.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AK008867, AK036439, AL928546
    Consensus CDS
    CCDS16060.1
    UniProtKB/Swiss-Prot
    Q9Z0T9
    Related
    ENSMUSP00000054944, OTTMUSP00000013748, ENSMUST00000059888, OTTMUST00000030629
    Conserved Domains (3) summary
    pfam08725
    Location:730775
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam00362
    Location:30454
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:624706
    Integrin_B_tail; Integrin beta tail domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    60598292..60722603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498808.2XP_006498871.1  

    See identical proteins and their annotated locations for XP_006498871.1

    UniProtKB/Swiss-Prot
    Q9Z0T9
    Conserved Domains (3) summary
    pfam08725
    Location:730775
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam00362
    Location:30454
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:624706
    Integrin_B_tail; Integrin beta tail domain
  2. XM_006498809.1XP_006498872.1  

    See identical proteins and their annotated locations for XP_006498872.1

    UniProtKB/Swiss-Prot
    Q9Z0T9
    Conserved Domains (3) summary
    pfam08725
    Location:730775
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam00362
    Location:30454
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:624706
    Integrin_B_tail; Integrin beta tail domain
  3. XM_006498811.2XP_006498874.1  

    See identical proteins and their annotated locations for XP_006498874.1

    UniProtKB/Swiss-Prot
    Q9Z0T9
    Conserved Domains (3) summary
    pfam08725
    Location:730775
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam00362
    Location:30454
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:624706
    Integrin_B_tail; Integrin beta tail domain
  4. XM_006498810.2XP_006498873.1  

    See identical proteins and their annotated locations for XP_006498873.1

    UniProtKB/Swiss-Prot
    Q9Z0T9
    Conserved Domains (3) summary
    pfam08725
    Location:730775
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam00362
    Location:30454
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:624706
    Integrin_B_tail; Integrin beta tail domain

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    62295485..62419857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)