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    HAVCR2 hepatitis A virus cellular receptor 2 [ Homo sapiens (human) ]

    Gene ID: 84868, updated on 28-Jun-2015
    Official Symbol
    HAVCR2provided by HGNC
    Official Full Name
    hepatitis A virus cellular receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:18437
    See related
    Ensembl:ENSG00000135077; HPRD:16227; MIM:606652; Vega:OTTHUMG00000130249
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIM3; CD366; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2
    Summary
    The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
    Orthologs
    See HAVCR2 in Epigenomics, MapViewer
    Location:
    5q33.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (157085832..157109237, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (156512843..156536248, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene T-cell immunoglobulin and mucin domain containing 4 Neighboring gene apolipoprotein O pseudogene 1 Neighboring gene hepatitis A virus cellular receptor 1 Neighboring gene mediator complex subunit 7 Neighboring gene family with sequence similarity 71, member B

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag TIM-3 inhibits the release of HIV-1 in terms of reduced levels of CA and RT activity in virus particles, and induces the accumulation of cell-associated CA PubMed
    reverse transcriptase gag-pol Knockdown of TIM-3 by shRNA enhances relative HIV-1 RT activity in HIV-1 infected monocyte-derived macrophages PubMed
    gag-pol TIM-3 inhibits the release of HIV-1 in terms of reduced levels of CA and RT activity in virus particles, and induces the accumulation of cell-associated CA PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: MED7

    Clone Names

    • FLJ14428

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    hepatitis A virus cellular receptor 2
    Names
    hepatitis A virus cellular receptor 2
    T cell immunoglobulin mucin 3
    T cell immunoglobulin mucin-3
    T-cell immunoglobulin and mucin domain-containing protein 3
    T-cell immunoglobulin mucin family member 3
    T-cell immunoglobulin mucin receptor 3
    T-cell membrane protein 3
    kidney injury molecule-3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030444.1 RefSeqGene

      Range
      5001..28406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_032782.4NP_116171.3  hepatitis A virus cellular receptor 2 precursor

      See identical proteins and their annotated locations for NP_116171.3

      Status: REVIEWED

      Source sequence(s)
      AC011377, AF251707, AF450243, BP291914
      Consensus CDS
      CCDS4333.1
      UniProtKB/Swiss-Prot
      Q8TDQ0
      Related
      ENSP00000312002, OTTHUMP00000160742, ENST00000307851, OTTHUMT00000252574
      Conserved Domains (2) summary
      smart00410
      Location:26126
      IG_like; Immunoglobulin like
      cl11960
      Location:31121
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

      Range
      157085832..157109237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      155945610..155968997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)