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REN renin [ Homo sapiens (human) ]

Gene ID: 5972, updated on 30-Apr-2015
Official Symbol
RENprovided by HGNC
Official Full Name
reninprovided by HGNC
Primary source
HGNC:HGNC:9958
See related
Ensembl:ENSG00000143839; HPRD:01564; MIM:179820; Vega:OTTHUMG00000036059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNFJ2
Summary
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
Orthologs
See REN in MapViewer
Location:
1q32
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (204154816..204166337, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (204123944..204135465, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SRY (sex determining region Y)-box 13 Neighboring gene uncharacterized LOC101929441 Neighboring gene ethanolamine kinase 2 Neighboring gene uncharacterized LOC105371690 Neighboring gene KiSS-1 metastasis-suppressor

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Renin cleaves HIV-1 Gag to enhance HIV-1 replication in human T cells PubMed
gag Renin modulates HIV-1 replication by enhancing HIV-1 Gag. CA/p24, and genomic RNA expressions in human T cells PubMed
capsid gag Renin modulates HIV-1 replication by enhancing HIV-1 Gag. CA/p24, and genomic RNA expressions in human T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10761

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aspartic-type endopeptidase activity EXP
Inferred from Experiment
more info
 
aspartic-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
insulin-like growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
angiotensin maturation IDA
Inferred from Direct Assay
more info
PubMed 
angiotensin maturation TAS
Traceable Author Statement
more info
 
beta-amyloid metabolic process IEA
Inferred from Electronic Annotation
more info
 
cell maturation IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
drinking behavior IEA
Inferred from Electronic Annotation
more info
 
hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
mesonephros development IEA
Inferred from Electronic Annotation
more info
 
NOT protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
renin-angiotensin regulation of aldosterone production IEA
Inferred from Electronic Annotation
more info
 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
response to cGMP IEA
Inferred from Electronic Annotation
more info
 
response to immobilization stress IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
renin
Names
renin
angiotensin-forming enzyme
angiotensinogenase
renin precursor, renal
NP_000528.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012122.1 RefSeqGene

    Range
    5001..16522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000537.3NP_000528.1  renin preproprotein

    See identical proteins and their annotated locations for NP_000528.1

    Status: REVIEWED

    Source sequence(s)
    BC033474, BP321283
    Consensus CDS
    CCDS30981.1
    UniProtKB/Swiss-Prot
    P00797
    Related
    ENSP00000272190, OTTHUMP00000034311, ENST00000272190, OTTHUMT00000087891
    Conserved Domains (3) summary
    pfam07966
    Location:3356
    A1_Propeptide; A1 Propeptide
    cd05487
    Location:78405
    renin_like; Renin stimulates production of angiotensin and thus affects blood pressure
    pfam00026
    Location:85405
    Asp; Eukaryotic aspartyl protease

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    204154816..204166337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    205547624..205559145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)