Display Settings:

Format

Send to:

Choose Destination

Klrk1 killer cell lectin-like receptor subfamily K, member 1 [ Mus musculus (house mouse) ]

Gene ID: 27007, updated on 5-Apr-2015
Official Symbol
Klrk1provided by MGI
Official Full Name
killer cell lectin-like receptor subfamily K, member 1provided by MGI
Primary source
MGI:MGI:1196250
See related
Ensembl:ENSMUSG00000030149; Vega:OTTMUSG00000032505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nkg2d; NKG2-D; D6H12S2489E
Orthologs
See Klrk1 in MapViewer
Location:
6 F3; 6 63.44 cM
Exon count:
9
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (129610323..129623864, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (129560339..129573859, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor family E member 1 Neighboring gene killer cell lectin-like receptor, subfamily D, member 1 Neighboring gene killer cell lectin-like receptor subfamily C, member 3 Neighboring gene killer cell lectin-like receptor subfamily C, member 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
MHC class I protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
MHC class Ib receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
NKG2-D type II integral membrane protein
Names
NKG2-D type II integral membrane protein
NK cell receptor D
NKG2-D-activating NK receptor
natural killer cell group 2D

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083322.2NP_001076791.1  NKG2-D type II integral membrane protein isoform b

    See proteins identical to NP_001076791.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform b, which has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC171002, AF030313, BY207066
    Consensus CDS
    CCDS39661.1
    UniProtKB/Swiss-Prot
    O54709
    Related
    ENSMUSP00000093061, OTTMUSP00000043133, ENSMUST00000095412, OTTMUST00000080885
    Conserved Domains (1) summary
    cd03593
    Location:102216
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  2. NM_001286018.1NP_001272947.1  NKG2-D type II integral membrane protein isoform c

    See proteins identical to NP_001272947.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform c, which contains a distinct N-terminus and an additional internal in-frame segment, and is shorter, compared to isoform a.
    Source sequence(s)
    AC171002
    Consensus CDS
    CCDS71846.1
    UniProtKB/TrEMBL
    Q3TCW7
    Related
    ENSMUSP00000130398, ENSMUST00000168919
    Conserved Domains (2) summary
    cd03593
    Location:108222
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    PHA03097
    Location:70223
    PHA03097; C-type lectin-like protein; Provisional
  3. NM_033078.4NP_149069.1  NKG2-D type II integral membrane protein isoform a

    See proteins identical to NP_149069.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AA174479, AC171002, AK040436
    Consensus CDS
    CCDS39660.1
    UniProtKB/Swiss-Prot
    O54709
    UniProtKB/TrEMBL
    Q4FJM0
    Conserved Domains (1) summary
    cd03593
    Location:115229
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    129610323..129623864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241369.1XP_011239671.1  

    Conserved Domains (1) summary
    cd03593
    Location:115193
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    131334937..131348865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)