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FOXF2 forkhead box F2 [ Homo sapiens (human) ]

Gene ID: 2295, updated on 11-Sep-2014
Official Symbol
FOXF2provided by HGNC
Official Full Name
forkhead box F2provided by HGNC
Primary source
HGNC:HGNC:3810
See related
Ensembl:ENSG00000137273; HPRD:09131; MIM:603250; Vega:OTTHUMG00000016243
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKHL6; FREAC2; FREAC-2
Summary
FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. [provided by RefSeq, Jul 2008]
See FOXF2 in Epigenomics, MapViewer
Location:
6p25.3
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (1389834..1395597)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (1390069..1395832)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC285768 Neighboring gene forkhead box Q1 Neighboring gene microRNA 6720 Neighboring gene uncharacterized LOC102723944 Neighboring gene E74-like factor 2 pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
embryonic camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic digestive tract development IEA
Inferred from Electronic Annotation
more info
 
epithelial to mesenchymal transition NAS
Non-traceable Author Statement
more info
PubMed 
establishment of planar polarity of embryonic epithelium IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
genitalia development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
forkhead box protein F2
Names
forkhead box protein F2
forkhead-like 6
forkhead-related activator 2
forkhead-related protein FKHL6
forkhead-related transcription factor 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001452.1NP_001443.1  forkhead box protein F2

    See proteins identical to NP_001443.1

    Status: REVIEWED

    Source sequence(s)
    U13220
    Consensus CDS
    CCDS4472.1
    UniProtKB/Swiss-Prot
    Q12947
    Related
    ENSP00000259806, OTTHUMP00000017863, ENST00000259806, OTTHUMT00000043558
    Conserved Domains (1) summary
    cd00059
    Location:100177
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    1389834..1395597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    1261028..1266486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    1392174..1397939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)