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    Ntrk1 neurotrophic receptor tyrosine kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59109, updated on 29-Jun-2016
    Official Symbol
    Ntrk1provided by RGD
    Official Full Name
    neurotrophic receptor tyrosine kinase 1provided by RGD
    Primary source
    RGD:620144
    See related
    Ensembl:ENSRNOG00000013953
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Trk
    Summary
    a protooncogene; receptor that binds to nerve growth factor (NGF) [RGD, Feb 2006]
    Orthologs
    Location:
    2q34
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187143562..187160373, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (206548566..206565385, complement)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 11 Neighboring gene leucine rich repeat containing 71 Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene insulin receptor-related receptor Neighboring gene SH2 domain containing 2A

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GPI-linked ephrin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nerve growth factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nerve growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    NOT nerve growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    nerve growth factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nerve growth factor receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    nerve growth factor receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neurotrophin p75 receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane receptor protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane receptor protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Ras protein signal transduction TAS
    Traceable Author Statement
    more info
     
    Sertoli cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of MAPKK activity TAS
    Traceable Author Statement
    more info
     
    activation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
     
    activation of phospholipase C activity TAS
    Traceable Author Statement
    more info
     
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis involved in innervation ISO
    Inferred from Sequence Orthology
    more info
     
    axonogenesis involved in innervation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    behavioral response to formalin induced pain IEA
    Inferred from Electronic Annotation
    more info
     
    behavioral response to formalin induced pain ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to nerve growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to nicotine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    detection of mechanical stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of temperature stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ephrin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    innervation ISO
    Inferred from Sequence Orthology
    more info
     
    learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mechanoreceptor differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    mechanoreceptor differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    NOT negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nerve growth factor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nerve growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    neurotrophin TRK receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    neurotrophin TRK receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neurotrophin TRK receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    olfactory nerve development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    NOT positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    NOT positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    NOT positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    NOT positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of programmed cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    programmed cell death involved in cell development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to activity IDA
    Inferred from Direct Assay
    more info
     
    response to axon injury IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to electrical stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
     
    response to hydrostatic pressure IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nicotine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to nutrient levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to radiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    sympathetic nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    sympathetic nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transmembrane receptor protein serine/threonine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    high affinity nerve growth factor receptor
    Names
    TrkA neurotrophin receptor
    neurotrophic tyrosine kinase, receptor, type 1
    p140-TrkA
    slow nerve growth factor receptor
    trk
    trk-A
    trkA proto-oncogene receptor
    tropomyosin-related kinase A
    NP_067600.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021589.1NP_067600.1  high affinity nerve growth factor receptor precursor

      See identical proteins and their annotated locations for NP_067600.1

      Status: PROVISIONAL

      Source sequence(s)
      M85214
      UniProtKB/Swiss-Prot
      P35739
      Related
      ENSRNOP00000018961, ENSRNOT00000018961
      Conserved Domains (7) summary
      cd04971
      Location:301382
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:197284
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      pfam07679
      Location:196284
      I-set; Immunoglobulin I-set domain
      pfam07714
      Location:513784
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13855
      Location:93150
      LRR_8; Leucine rich repeat
      sd00031
      Location:6892
      LRR_1; leucine-rich repeat [structural motif]
      cl21453
      Location:507786
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      187143562..187160373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232746.2XP_006232808.1  

      UniProtKB/Swiss-Prot
      P35739
      Conserved Domains (7) summary
      cd04971
      Location:301382
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:197284
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      pfam07679
      Location:196284
      I-set; Immunoglobulin I-set domain
      pfam07714
      Location:507778
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13855
      Location:93150
      LRR_8; Leucine rich repeat
      sd00031
      Location:6892
      LRR_1; leucine-rich repeat [structural motif]
      cl21453
      Location:501780
      PKc_like; Protein Kinases, catalytic domain

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      167186754..167203558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)