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    IDO1 indoleamine 2,3-dioxygenase 1 [ Homo sapiens (human) ]

    Gene ID: 3620, updated on 8-Aug-2016
    Official Symbol
    IDO1provided by HGNC
    Official Full Name
    indoleamine 2,3-dioxygenase 1provided by HGNC
    Primary source
    HGNC:HGNC:6059
    See related
    Ensembl:ENSG00000131203 HPRD:00935; MIM:147435; Vega:OTTHUMG00000164057
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IDO; INDO; IDO-1
    Summary
    This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
    Orthologs
    Location:
    8p11.21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (39913809..39928790)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (39771328..39786309)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 18 Neighboring gene ADAM metallopeptidase domain 2 Neighboring gene polo like kinase 4 pseudogene Neighboring gene indoleamine 2,3-dioxygenase 2 Neighboring gene nuclear transcription factor Y subunit beta pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of indoleamine-pyrrole 2,3 dioxygenase (INDO) in human B cells PubMed
    env CCR5- or CXCR4-tropic HIV-1 induce the release of Indoleamine 2,3-dioxygenase (IDO) in plasmacytoid dendritic cells and this induction is inhibited by the blockade of HIV-1 gp120 interaction with CD4 by anti-CD4-Ab PubMed
    Tat tat HIV-1 and the viral protein Tat modulate the expression of indoleamine-pyrrole 2,3 dioxygenase (IDO1) in immature dendritic cells and monocyte-derived macrophages PubMed
    tat HIV-1 clade B Tat up-regulates IDO and down-regulates serotonin transporter (5-HTT) gene and protein expressions in immature dendritic cells PubMed
    tat HIV-1 Tat-treated human monocyte derived-dendritic cells inhibit CD4+ T cell proliferation in an IDO dependent mechanism PubMed
    tat HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells PubMed
    tat HIV-1 Tat upregulates indoleamine-pyrrole 2,3 dioxygenase (IDO1) expression in Jurkat T-cells PubMed
    tat HIV-1 Tat upregulates the expression of indoleamine-pyrrole 2,3 dioxygenase (IDO) mRNA in monocytes. The synthesis of IDO is greatly reduced in the presence of neutralizing anti-TNF antibodies PubMed
    Vpr vpr HIV-1 Vpr potentiates the suppression of indoleamine 2,3-dioxygenase by glucocorticoids via the glucocorticoid receptor pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    electron carrier activity TAS
    Traceable Author Statement
    more info
    PubMed 
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    indoleamine 2,3-dioxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    tryptophan 2,3-dioxygenase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    Process Evidence Code Pubs
    cytokine production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    female pregnancy TAS
    Traceable Author Statement
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    kynurenic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organismal response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of T cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell tolerance induction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chronic inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of type 2 immune response IEA
    Inferred from Electronic Annotation
    more info
     
    NOT regulation of activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    swimming behavior IEA
    Inferred from Electronic Annotation
    more info
     
    tryptophan catabolic process TAS
    Traceable Author Statement
    more info
     
    tryptophan catabolic process to kynurenine IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    smooth muscle contractile fiber IEA
    Inferred from Electronic Annotation
    more info
     
    stereocilium bundle IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    indoleamine 2,3-dioxygenase 1
    Names
    indolamine 2,3 dioxygenase
    indole 2,3-dioxygenase
    indoleamine-pyrrole 2,3-dioxygenase
    NP_002155.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028155.1 RefSeqGene

      Range
      5001..19982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002164.5NP_002155.1  indoleamine 2,3-dioxygenase 1

      See identical proteins and their annotated locations for NP_002155.1

      Status: REVIEWED

      Source sequence(s)
      AU137351, BC027882, BF094375, CD366252
      Consensus CDS
      CCDS47847.1
      UniProtKB/Swiss-Prot
      P14902
      Related
      ENSP00000430950, OTTHUMP00000225716, ENST00000518237, OTTHUMT00000376987
      Conserved Domains (1) summary
      pfam01231
      Location:13398
      IDO; Indoleamine 2,3-dioxygenase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      39913809..39928790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      39817930..39832909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)