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    Bdnf brain derived neurotrophic factor [ Mus musculus (house mouse) ]

    Gene ID: 12064, updated on 10-Sep-2016
    Official Symbol
    Bdnfprovided by MGI
    Official Full Name
    brain derived neurotrophic factorprovided by MGI
    Primary source
    MGI:MGI:88145
    See related
    Ensembl:ENSMUSG00000048482 Vega:OTTMUSG00000015122
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    The protein encoded by this gene is a member of the nerve growth factor family. It is involved in the growth, differentiation and survival of specific types of developing neurons both in the central nervous system (CNS) and the peripheral nervous system. It is also involved in regulating synaptic plasticity in the CNS. Expression of a similar gene in human is reduced in both Alzheimer's and Huntington disease patients. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]
    Orthologs
    Location:
    2 E3; 2 56.63 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (109674700..109727043)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (109514857..109567200)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene methyltransferase like 15 Neighboring gene kinesin family member 18A Neighboring gene ribosomal protein L17 pseudogene Neighboring gene high mobility group box 2 pseudogene Neighboring gene predicted gene, 39907

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
      Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cocaine addiction, organism-specific biosystem (from KEGG)
      Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • Cocaine addiction, conserved biosystem (from KEGG)
      Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • NGF processing, organism-specific biosystem (from REACTOME)
      NGF processing, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
      NRAGE signals death through JNK, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
      p75 NTR receptor-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neurotrophin TRKB receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neurotrophin TRKB receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    axon extension IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon target recognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to acid chemical IDA
    Inferred from Direct Assay
    more info
    PubMed 
    circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    collateral sprouting ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendrite extension IDA
    Inferred from Direct Assay
    more info
    PubMed 
    excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gamma-aminobutyric acid signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamate secretion IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    inhibitory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    learning ISO
    Inferred from Sequence Orthology
    more info
     
    learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mechanoreceptor differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mitochondrial electron transport, NADH to ubiquinone ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of striated muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of synaptic transmission, GABAergic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nerve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection extension ISO
    Inferred from Sequence Orthology
    more info
     
    neuron recognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT positive regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of collateral sprouting IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of collateral sprouting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of collateral sprouting ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucocorticoid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of collateral sprouting IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of retinal cell programmed cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of short-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic plasticity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    taste bud development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ureteric bud development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic, membrane-bounded vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial crista ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    brain-derived neurotrophic factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048139.1NP_001041604.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001041604.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477, AY057911
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      P21237
      UniProtKB/TrEMBL
      Q541P3
      Related
      ENSMUSP00000106680, OTTMUSP00000016088, ENSMUST00000111051, OTTMUST00000035863
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    2. NM_001048141.1NP_001041606.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001041606.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477, AY057913
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      P21237
      UniProtKB/TrEMBL
      Q541P3
      Related
      ENSMUSP00000106679, OTTMUSP00000016092, ENSMUST00000111050, OTTMUST00000035867
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    3. NM_001048142.1NP_001041607.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001041607.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477, AY057914
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      P21237
      UniProtKB/TrEMBL
      Q541P3
      Related
      ENSMUSP00000106674, OTTMUSP00000016093, ENSMUST00000111045, OTTMUST00000035868
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    4. NM_001285416.1NP_001272345.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001272345.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477, AY057910
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      P21237
      UniProtKB/TrEMBL
      Q541P3
      Related
      ENSMUSP00000106676, OTTMUSP00000016089, ENSMUST00000111047, OTTMUST00000035864
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    5. NM_001285417.1NP_001272346.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001272346.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477, AY231131
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      P21237
      UniProtKB/TrEMBL
      Q541P3
      Related
      ENSMUSP00000106672, OTTMUSP00000016095, ENSMUST00000111043, OTTMUST00000035870
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    6. NM_001285418.1NP_001272347.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001272347.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477, AY057909
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      P21237
      UniProtKB/TrEMBL
      Q541P3
      Related
      ENSMUSP00000106678, OTTMUSP00000016090, ENSMUST00000111049, OTTMUST00000035865
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    7. NM_001285419.1NP_001272348.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001272348.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477, AY057912
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      P21237
      UniProtKB/TrEMBL
      Q541P3
      Related
      ENSMUSP00000106675, OTTMUSP00000016091, ENSMUST00000111046, OTTMUST00000035866
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    8. NM_001285420.1NP_001272349.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001272349.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      P21237
      UniProtKB/TrEMBL
      Q541P3
      Related
      ENSMUSP00000135762, OTTMUSP00000056673, ENSMUST00000176893, OTTMUST00000101213
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    9. NM_001285421.1NP_001272350.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001272350.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      P21237
      UniProtKB/TrEMBL
      Q541P3
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    10. NM_001285422.1NP_001272351.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001272351.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      P21237
      UniProtKB/TrEMBL
      Q541P3
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    11. NM_001316310.1NP_001303239.1  brain-derived neurotrophic factor isoform 2 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477, AY231132
      UniProtKB/Swiss-Prot
      P21237
      UniProtKB/TrEMBL
      Q541P3
      Related
      ENSMUSP00000106673, OTTMUSP00000016094, ENSMUST00000111044, OTTMUST00000035869
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    12. NM_007540.4NP_031566.4  brain-derived neurotrophic factor isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). This isoform (1) may undergo proteolytic processing similar to isoform 2.
      Source sequence(s)
      AL732477, AY057908
      Consensus CDS
      CCDS38193.1
      UniProtKB/TrEMBL
      A2AII2, Q541P3
      Related
      ENSMUSP00000057989, OTTMUSP00000016087, ENSMUST00000053317, OTTMUST00000035862
      Conserved Domains (1) summary
      smart00140
      Location:143250
      NGF; Nerve growth factor (NGF or beta-NGF)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      109674700..109727043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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