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Itk IL2 inducible T cell kinase [ Mus musculus (house mouse) ]

Gene ID: 16428, updated on 26-Aug-2014
Official Symbol
Itkprovided by MGI
Official Full Name
IL2 inducible T cell kinaseprovided by MGI
Primary source
MGI:96621
Locus tag
RP23-273O7.1
See related
Ensembl:ENSMUSG00000020395; Vega:OTTMUSG00000005493
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Emt; Tsk; Tcsk
Location:
11 B1.1; 11 27.75 cM
Exon count:
18
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 11 NC_000077.6 (46325148..46389515, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene cytoplasmic FMR1 interacting protein 2 Neighboring gene fibronectin type III domain containing 9 Neighboring gene high mobility group box 1 pseudogene Neighboring gene predicted gene 12167 Neighboring gene family with sequence similarity 71, member B Neighboring gene mediator complex subunit 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NK T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
NK T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of phospholipase C activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
adaptive immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
interferon-gamma production IGI
Inferred from Genetic Interaction
more info
PubMed 
interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-4 production IGI
Inferred from Genetic Interaction
more info
PubMed 
interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell-cell junction IDA
Inferred from Direct Assay
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tyrosine-protein kinase ITK/TSK
Names
tyrosine-protein kinase ITK/TSK
kinase TLK
T-cell-specific kinase
interleukin-2-inducible T cell kinase
NP_001268894.1
NP_001268895.1
NP_001268896.1
NP_001268897.1
NP_034713.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281965.1NP_001268894.1  tyrosine-protein kinase ITK/TSK isoform 1

    See proteins identical to NP_001268894.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK153613, AL662806, BB843988, BY589043, D14042
    Consensus CDS
    CCDS70169.1
    UniProtKB/Swiss-Prot
    Q03526
    UniProtKB/TrEMBL
    Q3U5G1
    Related
    ENSMUSP00000104860, OTTMUSP00000029887, ENSMUST00000109237, OTTMUST00000061071
    Conserved Domains (5) summary
    cd05112
    Location:363618
    Blast Score: 1419
    PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
    cd10396
    Location:238345
    Blast Score: 560
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11908
    Location:180235
    Blast Score: 337
    SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
    cd01238
    Location:7154
    Blast Score: 543
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    pfam07714
    Location:368617
    Blast Score: 999
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_001281966.1NP_001268895.1  tyrosine-protein kinase ITK/TSK isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AK153613, BB843988, BY589043, D14042
    UniProtKB/Swiss-Prot
    Q03526
    UniProtKB/TrEMBL
    Q3U5G1
    Conserved Domains (5) summary
    cd05112
    Location:360615
    Blast Score: 1418
    PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
    cd10396
    Location:235342
    Blast Score: 560
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11908
    Location:177232
    Blast Score: 337
    SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
    cd01238
    Location:7148
    Blast Score: 560
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    pfam07714
    Location:365614
    Blast Score: 999
    Pkinase_Tyr; Protein tyrosine kinase
  3. NM_001281967.1NP_001268896.1  tyrosine-protein kinase ITK/TSK isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BB843988, BC028478
    Consensus CDS
    CCDS70168.1
    UniProtKB/TrEMBL
    Q5STT7
    Related
    ENSMUSP00000098864, OTTMUSP00000005642, ENSMUST00000101306, OTTMUST00000012227
    Conserved Domains (3) summary
    cd11908
    Location:174229
    Blast Score: 325
    SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
    cd01238
    Location:7148
    Blast Score: 544
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cl15255
    Location:232259
    Blast Score: 116
    SH2; Src homology 2 (SH2) domain
  4. NM_001281968.1NP_001268897.1  tyrosine-protein kinase ITK/TSK isoform 5

    See proteins identical to NP_001268897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses two alternate in-frame splice sites in the central coding region, compared to variant 1. The encoded isoform (5) is shorter, compared to isoform 1.
    Source sequence(s)
    AK153613, BB843988, BY589043, D14042
    UniProtKB/TrEMBL
    A1A560
    UniProtKB/Swiss-Prot
    Q03526
    UniProtKB/TrEMBL
    Q3U5G1
    Conserved Domains (5) summary
    cd05112
    Location:356611
    Blast Score: 1419
    PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
    cd10396
    Location:231338
    Blast Score: 560
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11908
    Location:173228
    Blast Score: 337
    SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
    cd01238
    Location:7147
    Blast Score: 546
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    pfam07714
    Location:361610
    Blast Score: 999
    Pkinase_Tyr; Protein tyrosine kinase
  5. NM_010583.3NP_034713.2  tyrosine-protein kinase ITK/TSK isoform 2

    See proteins identical to NP_034713.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK153613, BB843988, BY589043, D14042
    Consensus CDS
    CCDS24575.2
    UniProtKB/Swiss-Prot
    Q03526
    UniProtKB/TrEMBL
    Q3U5G1
    UniProtKB/TrEMBL
    Q5STT8
    Related
    ENSMUSP00000020664, OTTMUSP00000005641, ENSMUST00000020664, OTTMUST00000012226
    Conserved Domains (5) summary
    cd05112
    Location:357612
    Blast Score: 1419
    PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
    cd10396
    Location:232339
    Blast Score: 560
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11908
    Location:174229
    Blast Score: 338
    SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
    cd01238
    Location:7148
    Blast Score: 560
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    pfam07714
    Location:362611
    Blast Score: 999
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000077.6 

    Range
    46325148..46389515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000033.1 

    Range
    50911122..50975428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)