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    HTATIP2 HIV-1 Tat interactive protein 2 [ Homo sapiens (human) ]

    Gene ID: 10553, updated on 18-Aug-2016
    Official Symbol
    HTATIP2provided by HGNC
    Official Full Name
    HIV-1 Tat interactive protein 2provided by HGNC
    Primary source
    HGNC:HGNC:16637
    See related
    Ensembl:ENSG00000109854 HPRD:09288; MIM:605628; Vega:OTTHUMG00000166015
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CC3; TIP30; SDR44U1
    Orthologs
    Location:
    11p15.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (20363685..20383783)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (20385231..20405329)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376583 Neighboring gene developing brain homeobox 1 Neighboring gene protein arginine methyltransferase 3 Neighboring gene uncharacterized LOC105376584

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag interacts with HTATIP2 as demonstrated by proximity dependent biotinylation proteomics PubMed
    Tat tat HIV-1 Tat stimulates the phosphorylation of the RNA polymerase II C-terminal domain by TIP30 PubMed
    tat TIP30 interacts with amino acids 1-48 of HIV-1 Tat, including the Tat activation domain, and enhances Tat activation of the HIV-1 LTR promoter PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ26963

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    nuclear import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    oxidoreductase HTATIP2
    Names
    30 kDa HIV-1 TAT-interacting protein
    HIV-1 TAT-interactive protein 2
    HIV-1 Tat interactive protein 2, 30kDa
    HTATIP2
    Tat-interacting protein (30kD)
    short chain dehydrogenase/reductase family 44U, member 1
    NP_001091990.1
    NP_001091991.1
    NP_001091992.1
    NP_001091993.1
    NP_006401.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098520.1NP_001091990.1  oxidoreductase HTATIP2 isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK222969, BC015358, BP382529
      Consensus CDS
      CCDS44553.1
      UniProtKB/Swiss-Prot
      Q9BUP3
      Related
      ENSP00000392985, OTTHUMP00000231705, ENST00000419348, OTTHUMT00000387443
      Conserved Domains (1) summary
      cd05250
      Location:53265
      CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
    2. NM_001098521.1NP_001091991.1  oxidoreductase HTATIP2 isoform b

      See identical proteins and their annotated locations for NP_001091991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b, also known as CC3) with a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform.
      Source sequence(s)
      AC025972, AK222969, BC015358, DB450790
      Consensus CDS
      CCDS7852.1
      UniProtKB/Swiss-Prot
      Q9BUP3
      Related
      ENSP00000387876, OTTHUMP00000231704, ENST00000443524, OTTHUMT00000387442
      Conserved Domains (2) summary
      cd05250
      Location:19231
      CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
      COG0702
      Location:21171
      YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]
    3. NM_001098522.1NP_001091992.1  oxidoreductase HTATIP2 isoform b

      See identical proteins and their annotated locations for NP_001091992.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 5' end and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b, also known as CC3) with a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform.
      Source sequence(s)
      AI193677, AK222969, BC015358
      Consensus CDS
      CCDS7852.1
      UniProtKB/Swiss-Prot
      Q9BUP3
      Related
      ENSP00000394259, OTTHUMP00000231706, ENST00000451739, OTTHUMT00000387445
      Conserved Domains (2) summary
      cd05250
      Location:19231
      CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
      COG0702
      Location:21171
      YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]
    4. NM_001098523.1NP_001091993.1  oxidoreductase HTATIP2 isoform c

      See identical proteins and their annotated locations for NP_001091993.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR and coding region, compared to variant 1. The resulting isoform (c, also known as TC3) has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AF092095, AW963626
      Consensus CDS
      CCDS53613.1
      UniProtKB/Swiss-Prot
      Q9BUP3
      Related
      ENSP00000432107, OTTHUMP00000232023, ENST00000532081, OTTHUMT00000387446
      Conserved Domains (1) summary
      cl21454
      Location:19101
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    5. NM_006410.4NP_006401.3  oxidoreductase HTATIP2 isoform b

      See identical proteins and their annotated locations for NP_006401.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b, also known as CC3) with a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform.
      Source sequence(s)
      AK222969, BC015358, BF681178
      Consensus CDS
      CCDS7852.1
      UniProtKB/Swiss-Prot
      Q9BUP3
      Related
      ENSP00000397752, OTTHUMP00000231703, ENST00000421577, OTTHUMT00000387441
      Conserved Domains (2) summary
      cd05250
      Location:19231
      CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
      COG0702
      Location:21171
      YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      20363685..20383783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      20385142..20405237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)