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    Nedd4 neural precursor cell expressed, developmentally down-regulated 4 [ Mus musculus (house mouse) ]

    Gene ID: 17999, updated on 27-Jun-2015
    Official Symbol
    Nedd4provided by MGI
    Official Full Name
    neural precursor cell expressed, developmentally down-regulated 4provided by MGI
    Primary source
    MGI:MGI:97297
    See related
    Ensembl:ENSMUSG00000032216; Vega:OTTMUSG00000044728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nedd4a; Nedd4-1; AA959633; AL023035; AU019897; mKIAA0093; E430025J12Rik
    See Nedd4 in Epigenomics, MapViewer
    Location:
    9 D; 9 40.08 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (72662347..72749851)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (72510154..72597655)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L38 pseudogene Neighboring gene regulatory factor X, 7 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene 7265 Neighboring gene predicted gene 27204 Neighboring gene protogenin homolog (Gallus gallus)

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    coenzyme F420-0 gamma-glutamyl ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    coenzyme F420-2 alpha-glutamyl ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphothreonine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proline-rich region binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glycine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glycine ligase activity, elongating IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glycine ligase activity, initiating IEA
    Inferred from Electronic Annotation
    more info
     
    ribosomal S6-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    sodium channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tubulin-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    tubulin-glycine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adaptive immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocardial cushion development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endocardial cushion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of vascular endothelial growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    outflow tract morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Preferred Names
    E3 ubiquitin-protein ligase NEDD4
    Names
    E3 ubiquitin-protein ligase NEDD4
    NEDD-4
    neural precursor cell expressed developmentally down-regulated protein 4
    neural precursor cell expressed, developmentally down-regulated gene 4
    neural precursor cell expressed, developmentally down-regulated gene 4a
    neural precursor cell expressed, developmentally down-regulted gene 4
    NP_035020.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010890.3NP_035020.2  E3 ubiquitin-protein ligase NEDD4

      See identical proteins and their annotated locations for NP_035020.2

      Status: VALIDATED

      Source sequence(s)
      AK122203, AW553531, BB542352, BQ177728, BQ899954, BY059586, BY068934, CD807110, D85414
      Consensus CDS
      CCDS72275.1
      UniProtKB/TrEMBL
      B2RSC8
      UniProtKB/Swiss-Prot
      P46935
      Related
      ENSMUSP00000034740, OTTMUSP00000065729, ENSMUST00000034740, OTTMUST00000117592
      Conserved Domains (4) summary
      cd04033
      Location:79210
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00119
      Location:554883
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:530884
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:463493
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

      Range
      72662347..72749851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242672.1XP_011240974.1  

      Conserved Domains (4) summary
      smart00119
      Location:376705
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:352706
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:285315
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cl14603
      Location:132
      C2; C2 domain

    Alternate Mm_Celera

    Genomic

    1. AC_000031.1 Alternate Mm_Celera

      Range
      69852010..69939539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)