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    ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

    Gene ID: 10425, updated on 12-Jun-2016
    Official Symbol
    ARIH2provided by HGNC
    Official Full Name
    ariadne RBR E3 ubiquitin protein ligase 2provided by HGNC
    Primary source
    HGNC:HGNC:690
    See related
    Ensembl:ENSG00000177479 HPRD:09286; MIM:605615; Vega:OTTHUMG00000133547
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARI2; TRIAD1
    Summary
    The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]
    Orthologs
    Location:
    3p21
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (48918820..48985541)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48956265..49022974)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene PRKAR2A antisense RNA 1 Neighboring gene solute carrier family 25 member 20 Neighboring gene ariadne homolog 2 opposite strand Neighboring gene uncharacterized LOC105377079 Neighboring gene prolyl 4-hydroxylase, transmembrane Neighboring gene WD repeat domain 6 Neighboring gene DALR anticodon binding domain containing 3 Neighboring gene microRNA 425

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ10938, FLJ33921

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    E3 ubiquitin-protein ligase ARIH2
    Names
    all-trans retinoic acid inducible RING finger
    ariadne homolog 2
    protein ariadne-2 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317333.1NP_001304262.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC134028, AC137630, AK223550, AL110187, BG476221
      UniProtKB/Swiss-Prot
      O95376
      UniProtKB/TrEMBL
      Q53ET9, Q6IBL8
      Related
      ENSP00000403222, OTTHUMP00000210388, ENST00000449376, OTTHUMT00000345248
      Conserved Domains (2) summary
      smart00647
      Location:208270
      IBR; In Between Ring fingers
      pfam01485
      Location:298335
      IBR; IBR domain
    2. NM_001317334.1NP_001304263.1  E3 ubiquitin-protein ligase ARIH2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several 5' exons compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC137630, AL110187, BC000422, BG476221, BM928477
      UniProtKB/Swiss-Prot
      O95376
      Conserved Domains (2) summary
      smart00647
      Location:66128
      IBR; In Between Ring fingers
      pfam01485
      Location:156193
      IBR; IBR domain
    3. NM_006321.3NP_006312.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      See identical proteins and their annotated locations for NP_006312.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC137630, AL110187, BC000422, BG476221
      Consensus CDS
      CCDS2780.1
      UniProtKB/Swiss-Prot
      O95376
      UniProtKB/TrEMBL
      Q6IBL8
      Related
      ENSP00000348769, OTTHUMP00000164828, ENST00000356401, OTTHUMT00000257525
      Conserved Domains (2) summary
      smart00647
      Location:208270
      IBR; In Between Ring fingers
      pfam01485
      Location:298335
      IBR; IBR domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      48918820..48985541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533268.1XP_011531570.1  

      See identical proteins and their annotated locations for XP_011531570.1

      Conserved Domains (1) summary
      smart00647
      Location:208270
      IBR; In Between Ring fingers
    2. XM_017005532.1XP_016861021.1  

    3. XM_017005536.1XP_016861025.1  

    4. XM_011533266.1XP_011531568.1  

      See identical proteins and their annotated locations for XP_011531568.1

      Conserved Domains (1) summary
      smart00647
      Location:208270
      IBR; In Between Ring fingers
    5. XM_011533265.1XP_011531567.1  

      See identical proteins and their annotated locations for XP_011531567.1

      Conserved Domains (1) summary
      smart00647
      Location:208270
      IBR; In Between Ring fingers
    6. XM_017005541.1XP_016861030.1  

    7. XM_011533267.1XP_011531569.1  

      See identical proteins and their annotated locations for XP_011531569.1

      Conserved Domains (1) summary
      smart00647
      Location:208270
      IBR; In Between Ring fingers
    8. XM_017005531.1XP_016861020.1  

    9. XM_011533271.1XP_011531573.1  

      See identical proteins and their annotated locations for XP_011531573.1

      Conserved Domains (1) summary
      smart00647
      Location:136198
      IBR; In Between Ring fingers
    10. XM_017005539.1XP_016861028.1  

    11. XM_011533273.1XP_011531575.1  

      See identical proteins and their annotated locations for XP_011531575.1

      Conserved Domains (1) summary
      smart00647
      Location:124186
      IBR; In Between Ring fingers
    12. XM_017005540.1XP_016861029.1  

    13. XM_011533270.1XP_011531572.1  

      See identical proteins and their annotated locations for XP_011531572.1

      Conserved Domains (1) summary
      smart00647
      Location:136198
      IBR; In Between Ring fingers
    14. XM_017005537.1XP_016861026.1  

    15. XM_017005538.1XP_016861027.1  

    16. XM_017005534.1XP_016861023.1  

    17. XM_011533275.2XP_011531577.1  

      See identical proteins and their annotated locations for XP_011531577.1

      Conserved Domains (2) summary
      smart00647
      Location:136198
      IBR; In Between Ring fingers
      pfam01485
      Location:226263
      IBR; IBR domain
    18. XM_017005533.1XP_016861022.1  

    19. XM_017005535.1XP_016861024.1  

    20. XM_011533276.1XP_011531578.1  

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      48908366..48975548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)