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Tgfb1 transforming growth factor, beta 1 [ Mus musculus (house mouse) ]

Gene ID: 21803, updated on 19-Dec-2014
Official Symbol
Tgfb1provided by MGI
Official Full Name
transforming growth factor, beta 1provided by MGI
Primary source
MGI:MGI:98725
See related
Ensembl:ENSMUSG00000002603; Vega:OTTMUSG00000036027
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tgfb; Tgfb-1; TGFbeta1; TGF-beta1
See Tgfb1 in Epigenomics, MapViewer
Location:
7 A3; 7 13.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 7 NC_000073.6 (25687002..25704996)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 91 Neighboring gene B9 protein domain 2 Neighboring gene coiled-coil domain containing 97 Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
antigen binding ISO
Inferred from Sequence Orthology
more info
 
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
glycoprotein binding ISO
Inferred from Sequence Orthology
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transforming growth factor beta receptor binding TAS
Traceable Author Statement
more info
PubMed 
type II transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
type II transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
SMAD protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
SMAD protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains IDA
Inferred from Direct Assay
more info
PubMed 
branch elongation involved in mammary gland duct branching IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell activation IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cell growth IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cell-cell junction organization ISO
Inferred from Sequence Orthology
more info
 
cellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
common-partner SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
defense response TAS
Traceable Author Statement
more info
PubMed 
defense response to fungus, incompatible interaction ISO
Inferred from Sequence Orthology
more info
 
endoderm development IDA
Inferred from Direct Assay
more info
PubMed 
epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
evasion or tolerance of host defenses by virus ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix assembly IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
germ cell migration IDA
Inferred from Direct Assay
more info
PubMed 
growth IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
hyaluronan catabolic process ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
lens fiber cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
lymph node development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland branching involved in thelarche IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland development IDA
Inferred from Direct Assay
more info
PubMed 
mitotic cell cycle checkpoint ISO
Inferred from Sequence Orthology
more info
 
mononuclear cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
morphogenesis of a branching structure ISO
Inferred from Sequence Orthology
more info
 
myelination ISO
Inferred from Sequence Orthology
more info
 
myeloid dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
negative regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of immune response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macrophage cytokine production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ossification IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
negative regulation of skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
organ regeneration ISO
Inferred from Sequence Orthology
more info
 
pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphate-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NAD+ ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of SMAD protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of collagen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
positive regulation of exit from mitosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of histone acetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-17 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of isotype switching to IgA isotypes ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of odontogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
protein import into nucleus, translocation ISO
Inferred from Sequence Orthology
more info
 
protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of actin cytoskeleton reorganization IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of binding IDA
Inferred from Direct Assay
more info
PubMed 
regulation of branching involved in mammary gland duct morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cartilage development IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of miRNA metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
regulation of sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of striated muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulatory T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cholesterol ISO
Inferred from Sequence Orthology
more info
 
response to estradiol ISO
Inferred from Sequence Orthology
more info
 
response to organic substance ISO
Inferred from Sequence Orthology
more info
 
response to progesterone ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle tissue development TAS
Traceable Author Statement
more info
PubMed 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
tolerance induction to self antigen IMP
Inferred from Mutant Phenotype
more info
PubMed 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
blood microparticle ISO
Inferred from Sequence Orthology
more info
 
cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with microvillus ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
proteinaceous extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
transforming growth factor beta-1
Names
transforming growth factor beta-1
TGF-beta 1
TGF-beta-1
regulatory protein
transforming growth factor-beta 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011577.1NP_035707.1  transforming growth factor beta-1 precursor

    See proteins identical to NP_035707.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ009862
    Consensus CDS
    CCDS20993.1
    UniProtKB/Swiss-Prot
    P04202
    UniProtKB/TrEMBL
    Q3UNK5
    Related
    ENSMUSP00000002678, OTTMUSP00000051111, ENSMUST00000002678, OTTMUST00000092468
    Conserved Domains (2) summary
    pfam00019
    Location:290390
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:28261
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000073.6 

    Range
    25687002..25704996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000029.1 

    Range
    20295914..20313908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)