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    Cntnap1 contactin associated protein-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 53321, updated on 17-Sep-2016
    Official Symbol
    Cntnap1provided by MGI
    Official Full Name
    contactin associated protein-like 1provided by MGI
    Primary source
    MGI:MGI:1858201
    See related
    Ensembl:ENSMUSG00000017167 Vega:OTTMUSG00000002728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    shm; NCP1; p190; Caspr; Nrxn4; AI841080
    Orthologs
    Location:
    11; 11 D
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (101174649..101190723)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (101037431..101052034)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene tubulin, gamma 2 Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 Neighboring gene chemokine (C-C motif) receptor 10 Neighboring gene enhancer of zeste 1 polycomb repressive complex 2 subunit Neighboring gene receptor (calcitonin) activity modifying protein 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    shambling
    GeneReviews: Not available

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular process controlling posture IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuronal action potential propagation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    paranodal junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to paranode region of axon IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    paranode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    paranode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    contactin-associated protein 1
    Names
    MHDNIV
    caspr1
    neurexin 4 (contactin associated protein)
    neurexin IV
    neurexin-4
    paranodin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016782.2NP_058062.2  contactin-associated protein 1 precursor

      See identical proteins and their annotated locations for NP_058062.2

      Status: VALIDATED

      Source sequence(s)
      AF039833, AL590969, CN538743
      Consensus CDS
      CCDS25455.1
      UniProtKB/Swiss-Prot
      O54991
      Related
      ENSMUSP00000099398, OTTMUSP00000002577, ENSMUST00000103109, OTTMUST00000005414
      Conserved Domains (7) summary
      smart00294
      Location:13051323
      4.1m; putative band 4.1 homologues' binding motif
      smart00231
      Location:25169
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00282
      Location:200332
      LamG; Laminin G domain
      cd00057
      Location:37168
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:363514
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:545574
      EGF; EGF-like domain
      cl00085
      Location:585659
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      101174649..101190723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533728.3XP_006533791.1  

      See identical proteins and their annotated locations for XP_006533791.1

      Conserved Domains (7) summary
      smart00294
      Location:12281246
      4.1m; putative band 4.1 homologues' binding motif
      smart00231
      Location:192
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00282
      Location:123255
      LamG; Laminin G domain
      cd00057
      Location:191
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:286437
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:468497
      EGF; EGF-like domain
      cl00085
      Location:508582
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    2. XM_006533730.3XP_006533793.1  

      Conserved Domains (6) summary
      smart00231
      Location:25169
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00282
      Location:200332
      LamG; Laminin G domain
      cd00057
      Location:37168
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:363514
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:545574
      EGF; EGF-like domain
      cl00085
      Location:585659
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    3. XM_006533729.3XP_006533792.1  

      See identical proteins and their annotated locations for XP_006533792.1

      Conserved Domains (7) summary
      smart00294
      Location:12281246
      4.1m; putative band 4.1 homologues' binding motif
      smart00231
      Location:192
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00282
      Location:123255
      LamG; Laminin G domain
      cd00057
      Location:191
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:286437
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:468497
      EGF; EGF-like domain
      cl00085
      Location:508582
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
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