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    Gfi1 growth factor independent 1 [ Mus musculus (house mouse) ]

    Gene ID: 14581, updated on 25-Jul-2015
    Official Symbol
    Gfi1provided by MGI
    Official Full Name
    growth factor independent 1provided by MGI
    Primary source
    MGI:MGI:103170
    See related
    Ensembl:ENSMUSG00000029275; Vega:OTTMUSG00000033123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pal1; Gfi-1; Pal-1; AW495828
    Orthologs
    See Gfi1 in Epigenomics, MapViewer
    Location:
    5 F; 5 52.23 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (107716655..107726031, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (108145674..108153363, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene RNA polymerase II associated protein 2 Neighboring gene RIKEN cDNA A930041C12 gene Neighboring gene RIKEN cDNA 4930428O21 gene Neighboring gene RIKEN cDNA A430072P03 gene Neighboring gene predicted gene, 42147 Neighboring gene ecotropic viral integration site 5 Neighboring gene ubiquitin-conjugating enzyme E2D 2B

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    auditory receptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myeloid cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of calcidiol 1-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-6-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional repressor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    zinc finger protein Gfi-1
    Names
    growth factor independent protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267621.1NP_001254550.1  zinc finger protein Gfi-1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate 5' exon and thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a distinct and longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AC138666, AV261275
      Consensus CDS
      CCDS59680.1
      UniProtKB/TrEMBL
      H3BJM0
      Related
      ENSMUSP00000135039, ENSMUST00000065478
      Conserved Domains (4) summary
      COG5048
      Location:321483
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam13465
      Location:421446
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:381401
      ZF_C2H2; Zn binding site [ion binding]
      sd00019
      Location:437457
      ZF_C2H2; Zn binding site [ion binding]
    2. NM_010278.2NP_034408.1  zinc finger protein Gfi-1 isoform 1

      See identical proteins and their annotated locations for NP_034408.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AC138666, AV261275
      Consensus CDS
      CCDS57371.1
      UniProtKB/Swiss-Prot
      P70338
      Related
      ENSMUSP00000135884, OTTMUSP00000062808, ENSMUST00000031205, OTTMUST00000082810
      Conserved Domains (4) summary
      COG5048
      Location:255417
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam13465
      Location:355380
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:315335
      ZF_C2H2; Zn binding site [ion binding]
      sd00019
      Location:371391
      ZF_C2H2; Zn binding site [ion binding]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

      Range
      107716655..107726031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534791.2XP_006534854.2  

      See identical proteins and their annotated locations for XP_006534854.2

      UniProtKB/Swiss-Prot
      P70338
      Conserved Domains (4) summary
      COG5048
      Location:255417
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam13465
      Location:355380
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:315335
      ZF_C2H2; Zn binding site [ion binding]
      sd00019
      Location:371391
      ZF_C2H2; Zn binding site [ion binding]
    2. XM_011249409.1XP_011247711.1  

      See identical proteins and their annotated locations for XP_011247711.1

      UniProtKB/Swiss-Prot
      P70338
      Related
      ENSMUSP00000137229, OTTMUSP00000062809, ENSMUST00000159164, OTTMUST00000082811
      Conserved Domains (4) summary
      COG5048
      Location:255417
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam13465
      Location:355380
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:315335
      ZF_C2H2; Zn binding site [ion binding]
      sd00019
      Location:371391
      ZF_C2H2; Zn binding site [ion binding]
    3. XM_006534793.2XP_006534856.1  

      See identical proteins and their annotated locations for XP_006534856.1

      UniProtKB/Swiss-Prot
      P70338
      Conserved Domains (4) summary
      COG5048
      Location:255417
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam13465
      Location:355380
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:315335
      ZF_C2H2; Zn binding site [ion binding]
      sd00019
      Location:371391
      ZF_C2H2; Zn binding site [ion binding]
    4. XM_006534792.1XP_006534855.1  

      See identical proteins and their annotated locations for XP_006534855.1

      UniProtKB/Swiss-Prot
      P70338
      Conserved Domains (4) summary
      COG5048
      Location:255417
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam13465
      Location:355380
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:315335
      ZF_C2H2; Zn binding site [ion binding]
      sd00019
      Location:371391
      ZF_C2H2; Zn binding site [ion binding]
    5. XM_006534794.1XP_006534857.1  

      See identical proteins and their annotated locations for XP_006534857.1

      UniProtKB/Swiss-Prot
      P70338
      Conserved Domains (4) summary
      COG5048
      Location:255417
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam13465
      Location:355380
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:315335
      ZF_C2H2; Zn binding site [ion binding]
      sd00019
      Location:371391
      ZF_C2H2; Zn binding site [ion binding]

    Alternate Mm_Celera

    Genomic

    1. AC_000027.1 Alternate Mm_Celera

      Range
      104829261..104838431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)