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MET MET proto-oncogene, receptor tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 4233, updated on 21-Jul-2014
Official Symbol
METprovided by HGNC
Official Full Name
MET proto-oncogene, receptor tyrosine kinaseprovided by HGNC
Primary source
HGNC:7029
See related
Ensembl:ENSG00000105976; HPRD:01280; MIM:164860; Vega:OTTHUMG00000023299
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HGFR; AUTS9; RCCP2; c-Met
Summary
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Location:
7q31
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (116672357..116798386)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (116312406..116438440)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100996266 Neighboring gene caveolin 1, caveolae protein, 22kDa Neighboring gene KIAA1468 pseudogene Neighboring gene capping protein (actin filament) muscle Z-line, alpha 2 Neighboring gene RNA, 5S ribosomal pseudogene 239

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Hepatocellular carcinoma
MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
Compare labs
Renal cell carcinoma, papillary, 1
MedGen: C0007134 OMIM: 605074 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-09-06)

ISCA Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-09-06)

ISCA Genome Curation Page

NHGRI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
NHGRI GWA Catalog
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
hepatocyte growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
adult behavior IEA
Inferred from Electronic Annotation
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
brain development IEA
Inferred from Electronic Annotation
more info
 
branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
hepatocyte growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
liver development IEA
Inferred from Electronic Annotation
more info
 
muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
myoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
myotube differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hydrogen peroxide-mediated programmed cell death IMP
Inferred from Mutant Phenotype
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
peptidyl-tyrosine phosphorylation TAS
Traceable Author Statement
more info
 
placenta development IEA
Inferred from Electronic Annotation
more info
 
positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucose transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IEA
Inferred from Electronic Annotation
more info
 
semaphorin-plexin signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
hepatocyte growth factor receptor
Names
hepatocyte growth factor receptor
SF receptor
HGF receptor
HGF/SF receptor
proto-oncogene c-Met
scatter factor receptor
tyrosine-protein kinase Met
met proto-oncogene tyrosine kinase
NP_000236.2
NP_001120972.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008996.1 

    Range
    5001..130982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_662

mRNA and Protein(s)

  1. NM_000245.2NP_000236.2  hepatocyte growth factor receptor isoform b precursor

    See proteins identical to NP_000236.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AA278232, AI630755, BX648782, X54559
    Consensus CDS
    CCDS43636.1
    UniProtKB/Swiss-Prot
    P08581
    Related
    ENSP00000380860, OTTHUMP00000069168, ENST00000397752, OTTHUMT00000141947
    Conserved Domains (9) summary
    cd05058
    Location:10821343
    Blast Score: 1554
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    cd11278
    Location:25516
    Blast Score: 2546
    Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
    smart00630
    Location:52487
    Blast Score: 816
    Sema; semaphorin domain
    cd00603
    Location:839932
    Blast Score: 102
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:657740
    Blast Score: 300
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:563656
    Blast Score: 306
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:742837
    Blast Score: 272
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:519562
    Blast Score: 137
    PSI; Plexin repeat
    pfam07714
    Location:10781337
    Blast Score: 1044
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_001127500.1NP_001120972.1  hepatocyte growth factor receptor isoform a precursor

    See proteins identical to NP_001120972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC002543, AI630755, BC130420, BX648782, J02958
    Consensus CDS
    CCDS47689.1
    UniProtKB/Swiss-Prot
    P08581
    Conserved Domains (9) summary
    cd05058
    Location:11001361
    Blast Score: 1554
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    cd11278
    Location:25516
    Blast Score: 2548
    Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
    smart00630
    Location:52487
    Blast Score: 816
    Sema; semaphorin domain
    cd00603
    Location:857950
    Blast Score: 102
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:657740
    Blast Score: 300
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:563656
    Blast Score: 306
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:519562
    Blast Score: 136
    PSI; Plexin repeat
    pfam07714
    Location:10961355
    Blast Score: 1044
    Pkinase_Tyr; Protein tyrosine kinase
    cl15674
    Location:742855
    Blast Score: 243
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    116672357..116798386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715991.1XP_006716054.1  

    See proteins identical to XP_006716054.1

    UniProtKB/TrEMBL
    B4DLF5
    Conserved Domains (8) summary
    cd05058
    Location:652913
    Blast Score: 1555
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    cd00603
    Location:409502
    Blast Score: 100
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:227310
    Blast Score: 296
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:133226
    Blast Score: 302
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:89132
    Blast Score: 138
    PSI; Plexin repeat
    pfam07714
    Location:648907
    Blast Score: 1044
    Pkinase_Tyr; Protein tyrosine kinase
    cl15674
    Location:312407
    Blast Score: 271
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:186
    Blast Score: 446
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  2. XM_006715988.1XP_006716051.1  

    Conserved Domains (9) summary
    cd05058
    Location:11191380
    Blast Score: 1553
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    cd11278
    Location:44535
    Blast Score: 2548
    Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
    smart00630
    Location:71506
    Blast Score: 816
    Sema; semaphorin domain
    cd00603
    Location:876969
    Blast Score: 103
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:676759
    Blast Score: 300
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:582675
    Blast Score: 306
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:538581
    Blast Score: 136
    PSI; Plexin repeat
    pfam07714
    Location:11151374
    Blast Score: 1044
    Pkinase_Tyr; Protein tyrosine kinase
    cl15674
    Location:761874
    Blast Score: 243
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  3. XM_006715989.1XP_006716052.1  

    Conserved Domains (9) summary
    cd05058
    Location:11011362
    Blast Score: 1554
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    cd11278
    Location:44535
    Blast Score: 2546
    Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
    smart00630
    Location:71506
    Blast Score: 816
    Sema; semaphorin domain
    cd00603
    Location:858951
    Blast Score: 103
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:676759
    Blast Score: 300
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:582675
    Blast Score: 306
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:761856
    Blast Score: 272
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:538581
    Blast Score: 136
    PSI; Plexin repeat
    pfam07714
    Location:10971356
    Blast Score: 1044
    Pkinase_Tyr; Protein tyrosine kinase
  4. XM_006715990.1XP_006716053.1  

    See proteins identical to XP_006716053.1

    UniProtKB/TrEMBL
    B4DLF5
    Conserved Domains (8) summary
    cd05058
    Location:652913
    Blast Score: 1555
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    cd00603
    Location:409502
    Blast Score: 100
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:227310
    Blast Score: 296
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:133226
    Blast Score: 302
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:89132
    Blast Score: 138
    PSI; Plexin repeat
    pfam07714
    Location:648907
    Blast Score: 1044
    Pkinase_Tyr; Protein tyrosine kinase
    cl15674
    Location:312407
    Blast Score: 271
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:186
    Blast Score: 446
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    110678023..110804134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    116246063..116372044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)