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    Alox12b arachidonate 12-lipoxygenase, 12R type [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287425, updated on 4-Jul-2015
    Official Symbol
    Alox12bprovided by RGD
    Official Full Name
    arachidonate 12-lipoxygenase, 12R typeprovided by RGD
    Primary source
    RGD:1305330
    See related
    Ensembl:ENSRNOG00000022210
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    See Alox12b in MapViewer
    Location:
    10q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55744646..55756524)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (55487702..55499580)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L35a-like Neighboring gene ribosomal protein L37a-like Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene arachidonate 15-lipoxygenase, type B Neighboring gene guanylate cyclase 2E

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    arachidonate 12-lipoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    arachidonate 12-lipoxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    linoleate 9S-lipoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    linoleate 9S-lipoxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    arachidonic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    arachidonic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    NOT bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    biological_process ND
    No biological Data available
    more info
     
    ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    ceramide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    establishment of skin barrier ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of skin barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    hepoxilin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    linoleic acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lipoxygenase pathway ISO
    Inferred from Sequence Orthology
    more info
     
    lipoxygenase pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of mucus secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mucus secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein lipidation ISO
    Inferred from Sequence Orthology
    more info
     
    protein lipidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sphingolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    sphingolipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    arachidonate 12-lipoxygenase, 12R-type
    Names
    12R-LOX
    12R-lipoxygenase
    epidermis-type lipoxygenase 12
    NP_001034466.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039377.1NP_001034466.1  arachidonate 12-lipoxygenase, 12R-type

      See identical proteins and their annotated locations for NP_001034466.1

      Status: PROVISIONAL

      Source sequence(s)
      AY903231
      UniProtKB/Swiss-Prot
      Q2KMM4
      Related
      ENSRNOP00000033009, ENSRNOT00000039535
      Conserved Domains (2) summary
      cd01753
      Location:2116
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:238692
      Lipoxygenase; Lipoxygenase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      55744646..55756524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      53028472..53040383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)