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    Mtor mechanistic target of rapamycin (serine/threonine kinase) [ Mus musculus (house mouse) ]

    Gene ID: 56717, updated on 30-Aug-2015
    Official Symbol
    Mtorprovided by MGI
    Official Full Name
    mechanistic target of rapamycin (serine/threonine kinase)provided by MGI
    Primary source
    MGI:MGI:1928394
    See related
    Ensembl:ENSMUSG00000028991; Vega:OTTMUSG00000010950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FRAP; flat; FRAP2; Frap1; RAFT1; RAPT1; AI327068; 2610315D21Rik
    Orthologs
    See Mtor in Epigenomics, MapViewer
    Location:
    4 78.76 cM; 4 E1
    Exon count:
    58
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (148448582..148557685)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (147822691..147931794)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene patched domain containing 2 Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene angiopoietin-like 7 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene exosome component 10 Neighboring gene spermidine synthase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    flat-top
    GeneReviews: Not available

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC118056

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase III type 1 promoter DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase III type 2 promoter DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase III type 3 promoter DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    TFIIIC-class transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    drug binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell projection organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to nutrient levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    energy reserve metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ cell development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart valve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    maternal process involved in female pregnancy ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of NFAT protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell size IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of cholangiocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of iodide transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of muscle atrophy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholangiocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of granulosa cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lamellipodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of myotube differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron maturation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of skeletal muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase III promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of carbohydrate utilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of membrane permeability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of response to food ISO
    Inferred from Sequence Orthology
    more info
     
    response to amino acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to amino acid ISO
    Inferred from Sequence Orthology
    more info
     
    response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    response to insulin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to morphine ISO
    Inferred from Sequence Orthology
    more info
     
    response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    social behavior ISO
    Inferred from Sequence Orthology
    more info
     
    spinal cord development ISO
    Inferred from Sequence Orthology
    more info
     
    visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    voluntary musculoskeletal movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    TORC1 complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    TORC2 complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    endomembrane system ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    macromolecular complex ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    serine/threonine-protein kinase mTOR
    Names
    FK506 binding protein 12-rapamycin associated protein 1
    FK506-binding protein 12-rapamycin complex-associated protein 1
    FKBP-rapamycin associated protein (FRAP)
    FKBP-rapamycin-associated protein FRAP
    FKBP12-rapamycin complex-associated protein
    angiopoietin-like factor CDT6
    mammalian target of rapamycin
    rapamycin target protein 1
    NP_064393.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020009.2NP_064393.2  serine/threonine-protein kinase mTOR

      See identical proteins and their annotated locations for NP_064393.2

      Status: VALIDATED

      Source sequence(s)
      BC112904, CJ130100
      Consensus CDS
      CCDS18937.1
      UniProtKB/Swiss-Prot
      Q9JLN9
      Related
      ENSMUSP00000099510, OTTMUSP00000011776, ENSMUST00000103221, OTTMUST00000025684
      Conserved Domains (6) summary
      COG5032
      Location:3632549
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      pfam02260
      Location:25192549
      FATC; FATC domain
      pfam08771
      Location:20152114
      Rapamycin_bind; Rapamycin binding domain
      pfam11865
      Location:8541024
      DUF3385; Domain of unknown function (DUF3385)
      pfam13513
      Location:748805
      HEAT_EZ; HEAT-like repeat
      cd05169
      Location:21532431
      PIKKc_TOR; Catalytic domain of Target of Rapamycin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

      Range
      148448582..148557685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539077.1XP_006539140.1  

      Conserved Domains (6) summary
      pfam02259
      Location:8011188
      FAT; FAT domain
      pfam02260
      Location:17991829
      FATC; FATC domain
      pfam08771
      Location:12951394
      Rapamycin_bind; Rapamycin binding domain
      pfam11865
      Location:134304
      DUF3385; Domain of unknown function (DUF3385)
      pfam13513
      Location:2885
      HEAT_EZ; HEAT-like repeat
      cd05169
      Location:14331711
      PIKKc_TOR; Catalytic domain of Target of Rapamycin

    Reference GRCm38.p3 NOD/MrkTac

    Genomic

    1. NT_166299.2 Reference GRCm38.p3 NOD/MrkTac

      Range
      1861191..1971030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000026.1 Alternate Mm_Celera

      Range
      150709332..150819308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)