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Mapk8 mitogen-activated protein kinase 8 [ Mus musculus (house mouse) ]

Gene ID: 26419, updated on 3-May-2015
Official Symbol
Mapk8provided by MGI
Official Full Name
mitogen-activated protein kinase 8provided by MGI
Primary source
MGI:MGI:1346861
See related
Ensembl:ENSMUSG00000021936; Vega:OTTMUSG00000018229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JNK; JNK1; Prkm8; SAPK1; AI849689
Orthologs
See Mapk8 in MapViewer
Location:
14; 14 B
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 14 NC_000080.6 (33377898..33447214, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (34191084..34260344, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinases regulatory subunit 1 pseudogene Neighboring gene Rho GTPase activating protein 22 Neighboring gene predicted gene, 41130 Neighboring gene predicted gene 626 Neighboring gene protein tyrosine phosphatase, non-receptor type 20

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase regulator activity ISO
Inferred from Sequence Orthology
more info
 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
JNK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
JUN phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
JUN phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
JUN phosphorylation ISO
Inferred from Sequence Orthology
more info
 
cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to nitric oxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of dorsal identity ISO
Inferred from Sequence Orthology
more info
PubMed 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
neuronal stem cell maintenance ISO
Inferred from Sequence Orthology
more info
 
ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cyclase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of determination of dorsal identity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
programmed necrotic cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of histone deacetylation ISO
Inferred from Sequence Orthology
more info
 
regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to UV ISO
Inferred from Sequence Orthology
more info
 
response to cadmium ion IGI
Inferred from Genetic Interaction
more info
PubMed 
response to heat ISO
Inferred from Sequence Orthology
more info
 
response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
type B pancreatic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
mitogen-activated protein kinase 8
Names
mitogen-activated protein kinase 8
JNK1 beta1 protein kinase
MAP kinase 8
MAPK 8
c-Jun N-terminal kinase 1
mitogen activated protein kinase 8
protein kinase mitogen-activated 8
stress-activated protein kinase JNK1
NP_057909.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016700.4NP_057909.1  mitogen-activated protein kinase 8

    See identical proteins and their annotated locations for NP_057909.1

    Status: VALIDATED

    Source sequence(s)
    AI849689, AK043102, AK047936, AK053062, AK162915, BB619635
    Consensus CDS
    CCDS36869.1
    UniProtKB/TrEMBL
    Q544A0
    UniProtKB/Swiss-Prot
    Q91Y86
    Related
    ENSMUSP00000107576, OTTMUSP00000019790, ENSMUST00000111945, OTTMUST00000044046
    Conserved Domains (2) summary
    smart00220
    Location:26321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p3 C57BL/6J

    Range
    33377898..33447214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519031.2XP_006519094.1  

    See identical proteins and their annotated locations for XP_006519094.1

    UniProtKB/TrEMBL
    G3X8U9
    Conserved Domains (2) summary
    smart00220
    Location:26321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  2. XM_006519030.2XP_006519093.1  

    See identical proteins and their annotated locations for XP_006519093.1

    UniProtKB/TrEMBL
    Q7TSJ7
    Conserved Domains (2) summary
    smart00220
    Location:26321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  3. XM_006519032.2XP_006519095.1  

    See identical proteins and their annotated locations for XP_006519095.1

    UniProtKB/TrEMBL
    A6P3E4
    Conserved Domains (2) summary
    smart00220
    Location:26321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  4. XM_006519033.2XP_006519096.1  

    Conserved Domains (1) summary
    cl21453
    Location:1180
    PKc_like; Catalytic domain of the Protein Kinase superfamily

Alternate Mm_Celera

Genomic

  1. AC_000036.1 Alternate Mm_Celera

    Range
    29636611..29705910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)