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Ephb1 Eph receptor B1 [ Mus musculus (house mouse) ]

Gene ID: 270190, updated on 8-Dec-2014
Official Symbol
Ephb1provided by MGI
Official Full Name
Eph receptor B1provided by MGI
Primary source
MGI:MGI:1096337
See related
Ensembl:ENSMUSG00000032537; Vega:OTTMUSG00000021086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Elk; Net; Cek6; Elkh; Hek6; AW488255; 9330129L11; C130099E04Rik; ENSMUSG00000074119
See Ephb1 in Epigenomics, MapViewer
Location:
9 F1; 9
Exon count:
16
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 9 NC_000075.6 (101922128..102354693, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 5161 Neighboring gene predicted gene 29521 Neighboring gene predicted gene, 31326 Neighboring gene predicted gene, 31233 Neighboring gene microRNA 7243 Neighboring gene predicted gene, 31176 Neighboring gene kyphoscoliosis peptidase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
axon guidance receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane-ephrin receptor activity ISO
Inferred from Sequence Orthology
more info
 
transmembrane-ephrin receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
central nervous system projection neuron axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
central nervous system projection neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cranial nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendritic spine development ISO
Inferred from Sequence Orthology
more info
PubMed 
dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
detection of temperature stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
immunological synapse formation ISO
Inferred from Sequence Orthology
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
optic nerve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
retinal ganglion cell axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
filopodium tip IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ephrin type-B receptor 1
Names
ephrin type-B receptor 1
NP_001161768.1
NP_775623.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168296.1NP_001161768.1  ephrin type-B receptor 1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a coding exon compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK036211, AK039530, BC057301, CT025594
    Consensus CDS
    CCDS52901.1
    UniProtKB/TrEMBL
    Q8CA63
    UniProtKB/Swiss-Prot
    Q8CBF3
    Related
    ENSMUSP00000082261, OTTMUSP00000023195, ENSMUST00000085169, OTTMUST00000049891
    Conserved Domains (8) summary
    cd05065
    Location:585841
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09551
    Location:867934
    SAM_EPH-B1; SAM domain of EPH-B1 subfamily of tyrosine kinase receptors
    smart00454
    Location:867932
    SAM; Sterile alpha motif
    cd10476
    Location:20195
    EphR_LBD_B1; Ligand Binding Domain of Ephrin type-B Receptor 1
    cd00063
    Location:417525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00185
    Location:255317
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
    pfam07714
    Location:585837
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:541607
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  2. NM_173447.3NP_775623.3  ephrin type-B receptor 1 isoform 1 precursor

    See proteins identical to NP_775623.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK036148, AK039530, BC057301
    Consensus CDS
    CCDS40742.1
    UniProtKB/TrEMBL
    Q8CA63
    UniProtKB/Swiss-Prot
    Q8CBF3
    Related
    ENSMUSP00000035129, OTTMUSP00000023194, ENSMUST00000035129, OTTMUST00000049888
    Conserved Domains (8) summary
    cd05065
    Location:614882
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09551
    Location:908975
    SAM_EPH-B1; SAM domain of EPH-B1 subfamily of tyrosine kinase receptors
    smart00454
    Location:908973
    SAM; Sterile alpha motif
    cd10476
    Location:20195
    EphR_LBD_B1; Ligand Binding Domain of Ephrin type-B Receptor 1
    cd00063
    Location:417525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00185
    Location:255317
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
    pfam07714
    Location:619878
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:541616
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000075.6 

    Range
    101922128..102354693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000031.1 

    Range
    101458328..101902746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)