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    Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 26926, updated on 4-Sep-2016
    Official Symbol
    Aifm1provided by MGI
    Official Full Name
    apoptosis-inducing factor, mitochondrion-associated 1provided by MGI
    Primary source
    MGI:MGI:1349419
    See related
    Ensembl:ENSMUSG00000036932 Vega:OTTMUSG00000017542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hq; AIF; Pdcd8; AIFsh2
    Orthologs
    Location:
    X 25.68 cM; X A6
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (48474944..48513563, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (45828121..45866603, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene BCL6 co-repressor-like 1 Neighboring gene E74-like factor 4 (ets domain transcription factor) Neighboring gene predicted gene, 39512 Neighboring gene RAB33A, member RAS oncogene family

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC5706

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    (R)-2-hydroxyglutarate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    (R)-2-hydroxyisocaproate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    2-hydroxytetrahydrofuran dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    3-hydroxymenthone dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    3-ketoglucose-reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    5-exo-hydroxycamphor dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity IEA
    Inferred from Electronic Annotation
    more info
     
    D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    D-xylose:NADP reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    FAD binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    L-arabinose 1-dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    L-arabinose:NADP reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    L-xylulose reductase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    NAD(P)H oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetoin dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    aldo-keto reductase (NADP) activity IEA
    Inferred from Electronic Annotation
    more info
     
    dihydrotestosterone 17-beta-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    electron-transferring-flavoprotein dehydrogenase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    epoxide dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    gluconate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    isocitrate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mevaldate reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on NAD(P)H ISO
    Inferred from Sequence Orthology
    more info
     
    phenylcoumaran benzylic ether reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    steroid dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    steroid dehydrogenase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
     
    steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    very long-chain-3-hydroxyacyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic mitochondrial changes TAS
    Traceable Author Statement
    more info
    PubMed 
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic DNA fragmentation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to oxidative stress TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial intermembrane space TAS
    Traceable Author Statement
    more info
    PubMed 
    mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    apoptosis-inducing factor 1, mitochondrial
    Names
    harlequin
    programmed cell death protein 8

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290364.1NP_001277293.1  apoptosis-inducing factor 1, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001277293.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and contains an alternate exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AA261021, AF100927, AL669901, BY250260
      Consensus CDS
      CCDS72375.1
      UniProtKB/Swiss-Prot
      Q9Z0X1
      UniProtKB/TrEMBL
      B1AU25
      Related
      ENSMUSP00000110595, OTTMUSP00000019158, ENSMUST00000114945, OTTMUST00000042631
      Conserved Domains (3) summary
      pfam00070
      Location:297381
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:145442
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14721
      Location:460588
      AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term
    2. NM_012019.3NP_036149.1  apoptosis-inducing factor 1, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_036149.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA261021, AF100927, AK133764, AL669901
      Consensus CDS
      CCDS30109.1
      UniProtKB/Swiss-Prot
      Q9Z0X1
      Related
      ENSMUSP00000041104, OTTMUSP00000019157, ENSMUST00000037349, OTTMUST00000042630
      Conserved Domains (4) summary
      pfam00070
      Location:301385
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:149446
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14721
      Location:464592
      AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term
      cl00057
      Location:47121
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      48474944..48513563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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