Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Xist inactive X specific transcripts [ Mus musculus (house mouse) ]

    Gene ID: 213742, updated on 3-Apr-2016
    Official Symbol
    Xistprovided by MGI
    Official Full Name
    inactive X specific transcriptsprovided by MGI
    Primary source
    MGI:MGI:98974
    See related
    Ensembl:ENSMUSG00000086503
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI314753; A430022B11
    Summary
    X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome. It is essential for the initiation and spread of X-inactivation. It silences hundreds of genes by recruiting and tethering repressive chromatin-modifying complexes to the inactive X chromosome. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]
    Orthologs
    Location:
    X D; X 46.15 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) X NC_000086.7 (103460373..103483233, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (100655712..100678572, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene cysteine-rich hydrophobic domain 1 Neighboring gene testis specific X-linked gene Neighboring gene X (inactive)-specific transcript, opposite strand Neighboring gene ribosomal protein S12, pseudogene 1 Neighboring gene 40S ribosomal protein S19-like

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ribonucleoprotein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    X chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_001463.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AL669964
      Related
      ENSMUST00000127786
    2. NR_001570.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is alternatively spliced in the 3' end and is shorter compared to variant 1.
      Source sequence(s)
      AL669964

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p3 C57BL/6J

      Range
      103460373..103483233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000042.1 Alternate Mm_Celera

      Range
      90362213..90385056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)