Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    ACPP acid phosphatase, prostate [ Homo sapiens (human) ]

    Gene ID: 55, updated on 3-Apr-2016
    Official Symbol
    ACPPprovided by HGNC
    Official Full Name
    acid phosphatase, prostateprovided by HGNC
    Primary source
    HGNC:HGNC:125
    See related
    Ensembl:ENSG00000014257 HPRD:01378; MIM:171790; Vega:OTTHUMG00000159650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACP3; 5'-NT; ACP-3
    Summary
    This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]
    Orthologs
    Location:
    3q22.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (132317367..132368302)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (132036211..132087146)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene copine 4 Neighboring gene transfer RNA-Cys (GCA) 9-1 Neighboring gene ribosomal protein L7 pseudogene 16 Neighboring gene g2/M phase-specific E3 ubiquitin-protein ligase-like Neighboring gene NIP7, nucleolar pre-rRNA processing protein pseudogene 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acid phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    choline binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    lysophosphatidic acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thiamine phosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    adenosine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of adenosine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    purine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thiamine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    Golgi cisterna IEA
    Inferred from Electronic Annotation
    more info
     
    apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    multivesicular body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    prostatic acid phosphatase
    Names
    5'-nucleotidase
    TMPase
    ecto-5'-nucleotidase
    prostatic acid phosphotase
    thiamine monophosphatase
    NP_001090.2
    NP_001127666.1
    NP_001278966.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099.4NP_001090.2  prostatic acid phosphatase isoform PAP precursor

      See identical proteins and their annotated locations for NP_001090.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the shorter, secreted isoform (PAP).
      Source sequence(s)
      AA578274, AC020633, BC008493, BC016344, DC383453
      Consensus CDS
      CCDS3073.1
      UniProtKB/Swiss-Prot
      P15309
      Related
      ENSP00000337471, OTTHUMP00000216106, ENST00000336375, OTTHUMT00000356699
      Conserved Domains (1) summary
      cd07061
      Location:34332
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
    2. NM_001134194.1NP_001127666.1  prostatic acid phosphatase isoform TM-PAP precursor

      See identical proteins and their annotated locations for NP_001127666.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs at the 3' end compared to variant 1 and encodes a longer isoform (TM-PAP) with a distinct C-terminus compared to isoform PAP. TM-PAP is a type 1 transmembrane protein.
      Source sequence(s)
      AW136372, BC007460, BC008493, BQ100881, DC383453
      Consensus CDS
      CCDS46916.1
      UniProtKB/Swiss-Prot
      P15309
      Related
      ENSP00000323036, OTTHUMP00000216108, ENST00000351273, OTTHUMT00000356701
      Conserved Domains (1) summary
      cd07061
      Location:34332
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
    3. NM_001292037.1NP_001278966.1  prostatic acid phosphatase isoform 3

      See identical proteins and their annotated locations for NP_001278966.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform PAP.
      Source sequence(s)
      AC020633, AK300540, DC383453
      Consensus CDS
      CCDS77818.1
      UniProtKB/Swiss-Prot
      P15309
      Related
      ENSP00000417744, OTTHUMP00000216107, ENST00000475741, OTTHUMT00000356700
      Conserved Domains (1) summary
      cd07061
      Location:34299
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

      Range
      132317367..132368302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512947.1XP_011511249.1  

      Conserved Domains (1) summary
      cd07061
      Location:34299
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
    2. XM_011512946.1XP_011511248.1  

      Conserved Domains (1) summary
      cd07061
      Location:34332
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      131999235..132050170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)