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    HOG1 mitogen-activated protein kinase HOG1 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 850803, updated on 3-Apr-2016
    Gene symbol
    HOG1
    Gene description
    mitogen-activated protein kinase HOG1
    Primary source
    SGD:S000004103
    Locus tag
    YLR113W
    Gene type
    protein coding
    RNA name
    mitogen-activated protein kinase HOG1
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SSK3
    See HOG1 in Map Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (371620..372927)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene thioredoxin peroxidase AHP1 Neighboring gene Ccw12p Neighboring gene tRNA Neighboring gene Avl9p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

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    • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
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    • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
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    • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
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    • MAPK signaling pathway - yeast, organism-specific biosystem (from KEGG)
      MAPK signaling pathway - yeast, organism-specific biosystemThe S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third...
    • MAPK signaling pathway - yeast, conserved biosystem (from KEGG)
      MAPK signaling pathway - yeast, conserved biosystemThe S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third...
    • Regulation of mitophagy - yeast, organism-specific biosystem (from KEGG)
      Regulation of mitophagy - yeast, organism-specific biosystemMitophagy, which refers to the selective elimination of impaired or excessive mitochondria, is considered to be the main mechanism for mitochondria quality and quantity control. In yeast, oxidative s...
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    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osmosensory signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of nuclear cell cycle DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter in response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to arsenic-containing substance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    mitogen-activated protein kinase HOG1
    NP_013214.1
    • Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII in osmotic shock; activates CDC28 by stimulating antisense RNA transcription; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; with Mrc1p defines novel S-phase checkpoint that prevent conflicts between DNA replication and transcription; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      371620..372927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182000.1NP_013214.1  mitogen-activated protein kinase HOG1 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_013214.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P32485
      Conserved Domains (2) summary
      smart00220
      Location:23301
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07856
      Location:12339
      STKc_Sty1_Hog1; Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases Sty1 and Hog1