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    Dnmt1 DNA methyltransferase (cytosine-5) 1 [ Mus musculus (house mouse) ]

    Gene ID: 13433, updated on 27-Jun-2015
    Official Symbol
    Dnmt1provided by MGI
    Official Full Name
    DNA methyltransferase (cytosine-5) 1provided by MGI
    Primary source
    MGI:MGI:94912
    See related
    Ensembl:ENSMUSG00000004099
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dnmt; MCMT; Met1; Cxxc9; MTase; Met-1; Dnmt1o; m.MmuI; MommeD2
    Orthologs
    See Dnmt1 in Epigenomics, MapViewer
    Location:
    9 A3; 9 7.66 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (20907205..20959888, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (20711653..20757317, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene peter pan homolog (Drosophila) Neighboring gene eukaryotic translation initiation factor 3, subunit G Neighboring gene microRNA 7081 Neighboring gene sphingosine-1-phosphate receptor 2 Neighboring gene mitochondrial ribosomal protein L4

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA (cytosine-5-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA (cytosine-5-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methyl-CpG binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    unmethylated CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    C-5 methylation of cytosine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA hypermethylation ISO
    Inferred from Sequence Orthology
    more info
     
    DNA methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA methylation on cytosine ISO
    Inferred from Sequence Orthology
    more info
     
    DNA methylation on cytosine within a CG sequence ISO
    Inferred from Sequence Orthology
    more info
     
    S-adenosylhomocysteine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    S-adenosylmethioninamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    S-adenosylmethionine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to amino acid stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    gene silencing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    maintenance of DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of DNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of histone H3-K9 methylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone H3-K4 methylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to antidepressant ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    replication fork IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    DNA (cytosine-5)-methyltransferase 1
    Names
    DNA (cytosine-5)-methyltransferase 1
    DNA MTase MmuI
    DNA methyltransferase MmuI
    NP_001186360.2
    NP_001186361.1
    NP_001186362.1
    NP_034196.5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199431.1NP_001186360.2  DNA (cytosine-5)-methyltransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_001186360.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1). This variant has two upstream in-frame AUGs but N-terminal sequencing and western analysis from PMID: 9830015 (Table I and Figure 2) support the use of the third in-frame AUG.
      Source sequence(s)
      AF162282, AK147143
      Consensus CDS
      CCDS57655.1
      UniProtKB/Swiss-Prot
      P13864
      UniProtKB/TrEMBL
      Q3UHZ3
      Related
      ENSMUSP00000004202, ENSMUST00000004202
      Conserved Domains (7) summary
      COG0270
      Location:11411594
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd04711
      Location:9691104
      BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
      cd04760
      Location:758881
      BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
      pfam02008
      Location:648694
      zf-CXXC; CXXC zinc finger domain
      pfam05029
      Location:124331
      TIMELESS_C; Timeless protein C terminal region
      pfam06464
      Location:16106
      DMAP_binding; DMAP1-binding Domain
      pfam12047
      Location:405540
      DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
    2. NM_001199432.1NP_001186361.1  DNA (cytosine-5)-methyltransferase 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site and contains a different first exon, which results in the use of a downstream, in-frame, start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AF036007, AF162282, AK136213, AK147143
      Consensus CDS
      CCDS57653.1
      UniProtKB/TrEMBL
      J3QNW0
      UniProtKB/Swiss-Prot
      P13864
      UniProtKB/TrEMBL
      Q3UHZ3
      UniProtKB/TrEMBL
      Q3UWN4
      Related
      ENSMUSP00000136982, ENSMUST00000177754
      Conserved Domains (6) summary
      COG0270
      Location:10221475
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd04711
      Location:850985
      BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
      cd04760
      Location:639762
      BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
      pfam02008
      Location:529575
      zf-CXXC; CXXC zinc finger domain
      pfam05029
      Location:106212
      TIMELESS_C; Timeless protein C terminal region
      pfam12047
      Location:286421
      DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
    3. NM_001199433.1NP_001186362.1  DNA (cytosine-5)-methyltransferase 1 isoform 4

      See identical proteins and their annotated locations for NP_001186362.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains a different first exon, which results in the use of a downstream, in-frame, start codon, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AF036009, AF175432, AK147143, CK636383
      Consensus CDS
      CCDS57654.1
      UniProtKB/Swiss-Prot
      P13864
      UniProtKB/TrEMBL
      Q3UHZ3
      Related
      ENSMUSP00000136669, ENSMUST00000178110
      Conserved Domains (5) summary
      COG0270
      Location:10231476
      Dcm; Site-specific DNA methylase [DNA replication, recombination, and repair]
      cd04711
      Location:851986
      BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
      cd04760
      Location:640763
      BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
      pfam02008
      Location:530576
      zf-CXXC; CXXC zinc finger domain
      pfam12047
      Location:287422
      DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
    4. NM_010066.4NP_034196.5  DNA (cytosine-5)-methyltransferase 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site, compared to variant 1. The resulting protein (isoform 2) is shorter by 1 amino acid when it is compared to isoform 1. This variant has two upstream in-frame AUGs but N-terminal sequencing and western analysis from PMID: 9830015 (Table I and Figure 2) support the use of the third in-frame AUG.
      Source sequence(s)
      AC170598, AF162282, AK147143
      UniProtKB/Swiss-Prot
      P13864
      UniProtKB/TrEMBL
      Q3UHZ3
      Conserved Domains (6) summary
      COG0270
      Location:11401593
      Dcm; Site-specific DNA methylase [DNA replication, recombination, and repair]
      cd04711
      Location:9681103
      BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
      cd04760
      Location:757880
      BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
      pfam02008
      Location:647693
      zf-CXXC; CXXC zinc finger domain
      pfam06464
      Location:16106
      DMAP_binding; DMAP1-binding Domain
      pfam12047
      Location:404539
      DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

      Range
      20907205..20959888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509988.1XP_006510051.1  

      Conserved Domains (7) summary
      COG0270
      Location:12001653
      Dcm; Site-specific DNA methylase [DNA replication, recombination, and repair]
      PRK13863
      Location:160353
      PRK13863; type IV secretion system T-DNA border endonuclease VirD2; Provisional
      cd04711
      Location:10281163
      BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
      cd04760
      Location:817940
      BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
      pfam02008
      Location:707753
      zf-CXXC; CXXC zinc finger domain
      pfam06464
      Location:69159
      DMAP_binding; DMAP1-binding Domain
      pfam12047
      Location:464599
      DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
    2. XM_006509987.1XP_006510050.1  

      Conserved Domains (6) summary
      COG0270
      Location:12011654
      Dcm; Site-specific DNA methylase [DNA replication, recombination, and repair]
      cd04711
      Location:10291164
      BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
      cd04760
      Location:818941
      BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
      pfam02008
      Location:708754
      zf-CXXC; CXXC zinc finger domain
      pfam06464
      Location:69159
      DMAP_binding; DMAP1-binding Domain
      pfam12047
      Location:465600
      DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
    3. XM_011242393.1XP_011240695.1  

      Conserved Domains (6) summary
      COG0270
      Location:10301483
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd04711
      Location:858993
      BAH_Dnmt1_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
      cd04760
      Location:647770
      BAH_Dnmt1_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG ...
      pfam02008
      Location:537583
      zf-CXXC; CXXC zinc finger domain
      pfam05029
      Location:114220
      TIMELESS_C; Timeless protein C terminal region
      pfam12047
      Location:294429
      DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain

    Alternate Mm_Celera

    Genomic

    1. AC_000031.1 Alternate Mm_Celera

      Range
      18175904..18228582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)