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    Ephx2 epoxide hydrolase 2, cytoplasmic [ Mus musculus (house mouse) ]

    Gene ID: 13850, updated on 19-Jul-2016
    Official Symbol
    Ephx2provided by MGI
    Official Full Name
    epoxide hydrolase 2, cytoplasmicprovided by MGI
    Primary source
    MGI:MGI:99500
    See related
    Ensembl:ENSMUSG00000022040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CEH; SEH; sEP; Eph2
    Orthologs
    Location:
    14 34.36 cM; 14 D
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (66084372..66124522, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (66703214..66743337, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene gulonolactone (L-) oxidase Neighboring gene a disintegrin and metallopeptidase domain 2 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) Neighboring gene PTK2 protein tyrosine kinase 2 beta

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    epoxide hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lipid phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    toxic substance binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    aromatic compound catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipid dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    prostaglandin production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    stilbene catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    bifunctional epoxide hydrolase 2
    Names
    cytosolic epoxide hydrolase
    epoxide hydratase
    epoxide hydrolase 2C
    soluble epoxide hydrolase
    NP_001258331.1
    NP_001258332.1
    NP_001258350.1
    NP_031966.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271402.1NP_001258331.1  bifunctional epoxide hydrolase 2 isoform b

      See identical proteins and their annotated locations for NP_001258331.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site at the 5' exon, differs in the 5' UTR, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC126272, AK002415
      Conserved Domains (4) summary
      cd01427
      Location:58150
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      pfam00561
      Location:231486
      Abhydrolase_1; alpha/beta hydrolase fold
      TIGR01509
      Location:1150
      HAD-SF-IA-v3; haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED
      cl21494
      Location:192244
      Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...
    2. NM_001271403.1NP_001258332.1  bifunctional epoxide hydrolase 2 isoform c precursor

      See identical proteins and their annotated locations for NP_001258332.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant is considered to be 5' complete based on evidence from PMID: 15601917. The encoded isoform (c) contains a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC126272, AY098585
      UniProtKB/Swiss-Prot
      P34914
      Conserved Domains (4) summary
      cd01427
      Location:93185
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      pfam00561
      Location:266521
      Abhydrolase_1; alpha/beta hydrolase fold
      TIGR01509
      Location:49185
      HAD-SF-IA-v3; haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED
      cl21494
      Location:227279
      Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...
    3. NM_001271421.1NP_001258350.1  bifunctional epoxide hydrolase 2 isoform d

      See identical proteins and their annotated locations for NP_001258350.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. This variant is considered to be 5' complete based on evidence from PMID: 17900570. The encoded isoform (d) has a shorter N-terminus than isoform a.
      Source sequence(s)
      AC126272, EF597241
      UniProtKB/TrEMBL
      A8JYK8
      Conserved Domains (4) summary
      cd01427
      Location:45137
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      pfam00561
      Location:218473
      Abhydrolase_1; alpha/beta hydrolase fold
      TIGR01509
      Location:1137
      HAD-SF-IA-v3; haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED
      cl21494
      Location:179231
      Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...
    4. NM_007940.4NP_031966.2  bifunctional epoxide hydrolase 2 isoform a

      See identical proteins and their annotated locations for NP_031966.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC126272, AK142714
      Consensus CDS
      CCDS27218.1
      UniProtKB/Swiss-Prot
      P34914
      UniProtKB/TrEMBL
      Q3UQ71
      Related
      ENSMUSP00000069209, ENSMUST00000070515
      Conserved Domains (4) summary
      cd01427
      Location:111203
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01509
      Location:5203
      HAD-SF-IA-v3; haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED
      pfam00561
      Location:257530
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:239379
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      66084372..66124522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)