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    Mmp2 matrix metallopeptidase 2 [ Mus musculus (house mouse) ]

    Gene ID: 17390, updated on 23-Aug-2015
    Official Symbol
    Mmp2provided by MGI
    Official Full Name
    matrix metallopeptidase 2provided by MGI
    Primary source
    MGI:MGI:97009
    See related
    Ensembl:ENSMUSG00000031740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GelA; Clg4a; MMP-2
    Orthologs
    See Mmp2 in Epigenomics, MapViewer
    Location:
    8 C5; 8 44.99 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (92827292..92853420)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (95351227..95377319)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene Iroquois related homeobox 6 (Drosophila) Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 36922 Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene calpain, small subunit 2 Neighboring gene predicted gene 2947

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel maturation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    bone trabecula formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to amino acid stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to estradiol stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    collagen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    collagen catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    embryo implantation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    face morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    intramembranous ossification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    peripheral nervous system axon regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prostate gland epithelium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal system morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    tissue remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    sarcomere IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    72 kDa type IV collagenase
    Names
    72 kDa gelatinase
    72kD gelatinase
    72kD type IV collagenase
    72kDa gelatinase
    72kDa type IV collagenase
    gelatinase A
    matrix metalloproteinase 2
    matrix metalloproteinase-2
    NP_032636.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008610.2NP_032636.1  72 kDa type IV collagenase precursor

      See identical proteins and their annotated locations for NP_032636.1

      Status: VALIDATED

      Source sequence(s)
      BC070430
      Consensus CDS
      CCDS22523.1
      UniProtKB/Swiss-Prot
      P33434
      UniProtKB/TrEMBL
      Q3UG07
      Related
      ENSMUSP00000034187, ENSMUST00000034187
      Conserved Domains (5) summary
      cd00062
      Location:343390
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00094
      Location:468662
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:118446
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:118446
      Peptidase_M10; Matrixin
      pfam01471
      Location:5297
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

      Range
      92827292..92853420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530751.1XP_006530814.1  

      Conserved Domains (7) summary
      smart00235
      Location:408489
      ZnMc; Zinc-dependent metalloprotease
      cd00062
      Location:385432
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00094
      Location:510704
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:118216
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:118218
      Peptidase_M10; Matrixin
      pfam01471
      Location:5297
      PG_binding_1; Putative peptidoglycan binding domain
      cl00064
      Location:429488
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    Alternate Mm_Celera

    Genomic

    1. AC_000030.1 Alternate Mm_Celera

      Range
      97157107..97183318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)