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Gata6 GATA binding protein 6 [ Mus musculus (house mouse) ]

Gene ID: 14465, updated on 21-Jul-2014
Official Symbol
Gata6provided by MGI
Official Full Name
GATA binding protein 6provided by MGI
Primary source
MGI:107516
See related
Ensembl:ENSMUSG00000005836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GATA-6; AA410133
See Gata6 in Epigenomics, MapViewer
Location:
18 A1; 18 5.63 cM
Exon count:
12
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 18 NC_000084.6 (11047691..11085636)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102639517 Neighboring gene PHD finger protein 14 pseudogene Neighboring gene RIKEN cDNA 9130001E16 gene Neighboring gene RIKEN cDNA 1010001N08 gene Neighboring gene uncharacterized LOC102639660 Neighboring gene predicted gene 7581

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding RNA polymerase II transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Clara cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
Type II pneumocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
cardiac muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle hypertrophy in response to stress IMP
Inferred from Mutant Phenotype
more info
 
cardiac muscle tissue development IGI
Inferred from Genetic Interaction
more info
 
cardiac vascular smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cellular response to BMP stimulus IDA
Inferred from Direct Assay
more info
 
cellular response to gonadotropin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
endodermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
endodermal cell fate determination IDA
Inferred from Direct Assay
more info
 
epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intestinal epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung saccule development IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transforming growth factor beta1 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transforming growth factor beta2 production ISO
Inferred from Sequence Orthology
more info
 
organ formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
pancreatic A cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipid metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to estrogen IDA
Inferred from Direct Assay
more info
PubMed 
response to growth factor ISO
Inferred from Sequence Orthology
more info
 
smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
tube morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
type B pancreatic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
transcription factor GATA-6
Names
transcription factor GATA-6
GATA-binding factor 6
GATA-binding protein 6

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010258.3NP_034388.2  transcription factor GATA-6

    See proteins identical to NP_034388.2

    Status: VALIDATED

    Source sequence(s)
    AI120546, AK142381, BB042635, BY084328
    Consensus CDS
    CCDS29059.1
    UniProtKB/Swiss-Prot
    Q61169
    Related
    ENSMUSP00000041774, ENSMUST00000047762
    Conserved Domains (2) summary
    cd00202
    Location:437488
    Blast Score: 213
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:147375
    Blast Score: 428
    GATA-N; GATA-type transcription activator, N-terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000084.6 

    Range
    11047691..11085636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525654.1XP_006525717.1  

    Conserved Domains (2) summary
    cd00202
    Location:455506
    Blast Score: 209
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:165393
    Blast Score: 433
    GATA-N; GATA-type transcription activator, N-terminal
  2. XM_006525655.1XP_006525718.1  

    See proteins identical to XP_006525718.1

    Conserved Domains (2) summary
    cd00202
    Location:437488
    Blast Score: 210
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:147375
    Blast Score: 428
    GATA-N; GATA-type transcription activator, N-terminal
  3. XM_006525656.1XP_006525719.1  

    See proteins identical to XP_006525719.1

    Conserved Domains (2) summary
    cd00202
    Location:437488
    Blast Score: 210
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:147375
    Blast Score: 428
    GATA-N; GATA-type transcription activator, N-terminal
  4. XM_006525652.1XP_006525715.1  

    Conserved Domains (2) summary
    cd00202
    Location:461512
    Blast Score: 210
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:171399
    Blast Score: 430
    GATA-N; GATA-type transcription activator, N-terminal
  5. XM_006525653.1XP_006525716.1  

    Conserved Domains (2) summary
    cd00202
    Location:461512
    Blast Score: 213
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:171399
    Blast Score: 430
    GATA-N; GATA-type transcription activator, N-terminal
  6. XM_006525657.1XP_006525720.1  

    See proteins identical to XP_006525720.1

    Conserved Domains (2) summary
    cd00202
    Location:437488
    Blast Score: 210
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:147375
    Blast Score: 428
    GATA-N; GATA-type transcription activator, N-terminal

Alternate Mm_Celera

Genomic

  1. AC_000040.1 

    Range
    11079782..11114690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)