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    ALOX15 arachidonate 15-lipoxygenase [ Homo sapiens (human) ]

    Gene ID: 246, updated on 23-Aug-2016
    Official Symbol
    ALOX15provided by HGNC
    Official Full Name
    arachidonate 15-lipoxygenaseprovided by HGNC
    Primary source
    HGNC:HGNC:433
    See related
    Ensembl:ENSG00000161905 HPRD:01067; MIM:152392; Vega:OTTHUMG00000090746
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    12-LOX; 15LOX-1; 15-LOX-1
    Orthologs
    Location:
    17p13.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (4630919..4641665, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4534214..4545583, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC400568 Neighboring gene uncharacterized LOC105371498 Neighboring gene RNA, U6 small nuclear 955, pseudogene Neighboring gene uncharacterized LOC105371499 Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene uncharacterized LOC101559451

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    arachidonate 12-lipoxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    arachidonate 12-lipoxygenase activity TAS
    Traceable Author Statement
    more info
     
    arachidonate 15-lipoxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    arachidonate 15-lipoxygenase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    arachidonate 15-lipoxygenase activity TAS
    Traceable Author Statement
    more info
     
    eoxin A4 synthase activity TAS
    Traceable Author Statement
    more info
     
    hepoxilin A3 synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hepoxilin-epoxide hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic cell clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    arachidonic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    arachidonic acid metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to interleukin-13 IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hepoxilin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    leukotriene metabolic process TAS
    Traceable Author Statement
    more info
     
    lipoxin A4 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lipoxygenase pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipoxygenase pathway TAS
    Traceable Author Statement
    more info
     
    negative regulation of adaptive immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ossification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylethanolamine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
     
    positive regulation of heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of engulfment of apoptotic cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of peroxisome proliferator activated receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    arachidonate 15-lipoxygenase
    Names
    12/15-lipoxygenase
    15-LOX
    15-lipooxygenase-1
    arachidonate 12-lipoxygenase, leukocyte-type
    arachidonate omega-6 lipoxygenase
    NP_001131.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001140.3NP_001131.3  arachidonate 15-lipoxygenase

      See identical proteins and their annotated locations for NP_001131.3

      Status: VALIDATED

      Source sequence(s)
      BC029032, M23892
      Consensus CDS
      CCDS11049.1
      UniProtKB/Swiss-Prot
      P16050
      Related
      ENSP00000293761, ENST00000293761
      Conserved Domains (2) summary
      cd01753
      Location:2111
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:137654
      Lipoxygenase; Lipoxygenase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      4630919..4641665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      4542997..4553746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)