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    Mecom MDS1 and EVI1 complex locus [ Mus musculus (house mouse) ]

    Gene ID: 14013, updated on 16-Aug-2016
    Official Symbol
    Mecomprovided by MGI
    Official Full Name
    MDS1 and EVI1 complex locusprovided by MGI
    Primary source
    MGI:MGI:95457
    See related
    Ensembl:ENSMUSG00000027684 Vega:OTTMUSG00000038143
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jbo; Mds; Evi1; Mds1; Evi-1; Prdm3; Znfpr1b1; Mds1-Evi1; D630039M04Rik
    Orthologs
    Location:
    3 A3; 3 12.66 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (29951296..30509783, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (29850218..30408409, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene EGF-like and EMI domain containing 1 Neighboring gene predicted gene, 42197 Neighboring gene predicted gene, 33206 Neighboring gene Mecom adjacent non-protein coding RNA Neighboring gene predicted gene 10258 Neighboring gene nuclear encoded tRNA valine 8 (anticodon AAC) Neighboring gene actin related protein T3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC183337, MGC184568

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    embryonic forelimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of cell number IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    neutrophil homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pericardium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    MDS1 and EVI1 complex locus protein EVI1
    Names
    MDS1 and EVI1 complex locus protein MDS1
    ecotropic viral integration site 1
    ecotropic virus integration site 1 protein
    myelodysplasia syndrome 1 homolog
    myelodysplasia syndrome 1 protein homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007963.2NP_031989.2  MDS1 and EVI1 complex locus protein EVI1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AI551247, AK085548, BC076620
      Consensus CDS
      CCDS17281.2
      UniProtKB/TrEMBL
      G3UZ13
      Related
      ENSMUSP00000134303, OTTMUSP00000055201, ENSMUST00000172694, OTTMUST00000098284
      Conserved Domains (4) summary
      PHA00733
      Location:333452
      PHA00733; hypothetical protein
      sd00017
      Location:402422
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:400422
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:414438
      zf-H2C2_2; Zinc-finger double domain
    2. NM_021442.2NP_067417.1  MDS1 and EVI1 complex locus protein EVI1 isoform 2

      See identical proteins and their annotated locations for NP_067417.1

      Status: PROVISIONAL

      Source sequence(s)
      AC119995, AL691419
      UniProtKB/Swiss-Prot
      Q9Z1L8
      Conserved Domains (1) summary
      cl02566
      Location:90118
      SET; SET domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      29951296..30509783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535387.2XP_006535450.1  

      See identical proteins and their annotated locations for XP_006535450.1

      Conserved Domains (4) summary
      smart00317
      Location:90194
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam00096
      Location:924946
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:938962
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:926946
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_011249663.1XP_011247965.1  

      Related
      ENSMUSP00000133310, OTTMUSP00000055196, ENSMUST00000173059, OTTMUST00000098277
      Conserved Domains (5) summary
      smart00317
      Location:62166
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG5048
      Location:263720
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam00096
      Location:562584
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:576600
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:564584
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. XM_011249658.1XP_011247960.1  

      Conserved Domains (5) summary
      PHA00733
      Location:819938
      PHA00733; hypothetical protein
      smart00317
      Location:62166
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam00096
      Location:886908
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:900924
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:888908
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. XM_011249656.1XP_011247958.1  

      Conserved Domains (4) summary
      smart00317
      Location:62166
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam00096
      Location:895917
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:909933
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:897917
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. XM_011249662.1XP_011247964.1  

      Conserved Domains (5) summary
      smart00317
      Location:62166
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG5048
      Location:263615
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam00096
      Location:572594
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:586610
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:574594
      ZF_C2H2; C2H2 Zn finger [structural motif]
    6. XM_011249657.1XP_011247959.1  

      Conserved Domains (5) summary
      PHA00733
      Location:820939
      PHA00733; hypothetical protein
      smart00317
      Location:62166
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam00096
      Location:887909
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:901925
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:889909
      ZF_C2H2; C2H2 Zn finger [structural motif]
    7. XM_011249661.2XP_011247963.1  

      See identical proteins and their annotated locations for XP_011247963.1

      Conserved Domains (3) summary
      pfam00096
      Location:734756
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:748772
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:736756
      ZF_C2H2; C2H2 Zn finger [structural motif]
    8. XM_006535394.2XP_006535457.1  

      See identical proteins and their annotated locations for XP_006535457.1

      Related
      ENSMUSP00000103905, OTTMUSP00000055194, ENSMUST00000108270, OTTMUST00000098275
      Conserved Domains (3) summary
      pfam00096
      Location:734756
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:748772
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:736756
      ZF_C2H2; C2H2 Zn finger [structural motif]
    9. XM_006535393.3XP_006535456.1  

      Conserved Domains (4) summary
      smart00317
      Location:768
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam00096
      Location:798820
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:812836
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:800820
      ZF_C2H2; C2H2 Zn finger [structural motif]
    10. XM_011249664.2XP_011247966.1  

      Conserved Domains (5) summary
      smart00317
      Location:99203
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG5048
      Location:300757
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam00096
      Location:599621
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:613637
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:601621
      ZF_C2H2; C2H2 Zn finger [structural motif]
    11. XM_011249660.2XP_011247962.1  

      Related
      ENSMUSP00000128563, OTTMUSP00000055203, ENSMUST00000166001, OTTMUST00000098286
      Conserved Domains (4) summary
      smart00317
      Location:62166
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam00096
      Location:895917
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:909933
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:897917
      ZF_C2H2; C2H2 Zn finger [structural motif]
    12. XM_011249659.2XP_011247961.1  

      Conserved Domains (4) summary
      smart00317
      Location:62166
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam00096
      Location:896918
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:910934
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:898918
      ZF_C2H2; C2H2 Zn finger [structural motif]
    13. XM_017319454.1XP_017174943.1