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Iqgap3 IQ motif containing GTPase activating protein 3 [ Mus musculus (house mouse) ]

Gene ID: 404710, updated on 3-Jun-2014
Official Symbol
Iqgap3provided by MGI
Official Full Name
IQ motif containing GTPase activating protein 3provided by MGI
Primary source
MGI:3028642
See related
Ensembl:ENSMUSG00000028068
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI593484; D030034H08
See Iqgap3 in Epigenomics, MapViewer
Location:
3 F1; 3 38.78 cM
Exon count :
38
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 3 NC_000069.6 (88082051..88121048)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene apolipoprotein A-I binding protein Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene transcription initiation factor TFIID subunit 4-like Neighboring gene myocyte enhancer factor 2D Neighboring gene RIKEN cDNA 1700113A16 gene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Ras GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Rho GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IMP
Inferred from Mutant Phenotype
more info
PubMed 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
IQ motif containing GTPase activating protein 3
Names
IQ motif containing GTPase activating protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033484.1NP_001028656.1  IQ motif containing GTPase activating protein 3

    See proteins identical to NP_001028656.1

    Status: VALIDATED

    Source sequence(s)
    BC068159, CA750580, CX200367
    Consensus CDS
    CCDS38478.1
    UniProtKB/TrEMBL
    F8VQ29
    Related
    ENSMUSP00000071715, ENSMUST00000071812
    Conserved Domains (4) summary
    smart00015
    Location:764782
    Blast Score: 98
    IQ; Calmodulin-binding motif
    cd00014
    Location:35147
    Blast Score: 186
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam03836
    Location:14331556
    Blast Score: 278
    RasGAP_C; RasGAP C-terminus
    cl02569
    Location:9881337
    Blast Score: 1608
    RasGAP; Ras GTPase Activating Domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000069.6 

    Range
    88082051..88121048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501643.1XP_006501706.1  

    Conserved Domains (3) summary
    smart00015
    Location:501519
    Blast Score: 97
    IQ; Calmodulin-binding motif
    pfam03836
    Location:11701293
    Blast Score: 277
    RasGAP_C; RasGAP C-terminus
    cl02569
    Location:7251074
    Blast Score: 1606
    RasGAP; Ras GTPase Activating Domain
  2. XM_006501644.1XP_006501707.1  

    Conserved Domains (4) summary
    smart00015
    Location:342360
    Blast Score: 97
    IQ; Calmodulin-binding motif
    cd00201
    Location:249274
    Blast Score: 83
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam03836
    Location:10111134
    Blast Score: 274
    RasGAP_C; RasGAP C-terminus
    cl02569
    Location:566915
    Blast Score: 1609
    RasGAP; Ras GTPase Activating Domain

Alternate Mm_Celera

Genomic

  1. AC_000025.1 

    Range
    88121650..88160680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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