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    apc adenomatous polyposis coli [ Danio rerio (zebrafish) ]

    Gene ID: 386762, updated on 25-Jul-2015
    Official Symbol
    apcprovided by ZNC
    Official Full Name
    adenomatous polyposis coliprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031112-7
    See related
    Ensembl:ENSDARG00000058868; Vega:OTTDARG00000035536
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    cb965; im:7150932; im:7152872
    Orthologs
    See apc in MapViewer
    Location:
    chromosome: 10
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    104 current GRCz10 (GCF_000002035.5) 10 NC_007121.6 (1812280..1865381)
    103 previous assembly Zv9 (GCF_000002035.4) 10 NC_007121.5 (1868423..1921518)

    Chromosome 10 - NC_007121.6Genomic Context describing neighboring genes Neighboring gene galactose-3-O-sulfotransferase 1b Neighboring gene erythrocyte membrane protein band 4.1 like 4A Neighboring gene C3a anaphylatoxin chemotactic receptor Neighboring gene teratocarcinoma-derived growth factor 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
     
    beta-catenin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Wnt signaling pathway involved in heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Wnt signaling pathway involved in somitogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    digestive system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic pectoral fin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocardium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endodermal digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eye photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart jogging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart looping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart valve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hepatocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    liver development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    midbrain-hindbrain boundary development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    muscle cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of microtubule depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    otic vesicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    posterior lateral line neuromast primordium migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of DNA methylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of retinoic acid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retinal ganglion cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retinoic acid receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    superior colliculus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    zona limitans intrathalamica formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    beta-catenin destruction complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    adenomatous polyposis coli protein
    Names
    adenomatosis polyposis coli

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143840.1NP_001137312.1  adenomatous polyposis coli protein

      Status: VALIDATED

      Source sequence(s)
      CU861476, CU915637
      Related
      ENSDARP00000139275, ENSDART00000158897
      Conserved Domains (6) summary
      pfam05937
      Location:25932754
      EB1_binding; EB-1 Binding Domain
      pfam05923
      Location:16071632
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:19812000
      SAMP; SAMP Motif
      pfam11414
      Location:123199
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      cd00020
      Location:604725
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05956
      Location:21722506
      APC_basic; APC basic domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz10 Primary Assembly

    Genomic

    1. NC_007121.6 Reference GRCz10 Primary Assembly

      Range
      1812280..1865381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155523.2XP_005155580.1  

      UniProtKB/TrEMBL
      F8W4Z3
      Related
      ENSDARP00000123835, OTTDARP00000039711, ENSDART00000149956, OTTDART00000050578
      Conserved Domains (6) summary
      pfam05937
      Location:25842745
      EB1_binding; EB-1 Binding Domain
      pfam05923
      Location:15981623
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:19721991
      SAMP; SAMP Motif
      pfam11414
      Location:123199
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      cd00020
      Location:595716
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05956
      Location:21632497
      APC_basic; APC basic domain