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hh hedgehog [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42737, updated on 8-Nov-2014
Official Symbol
hhprovided by FlyBase
Official Full Name
hedgehogprovided by FlyBase
Primary source
FLYBASE:FBgn0004644
Locus tag
Dmel_CG4637
Gene type
protein coding
RNA name
hedgehog
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0134654.19; anon-WO0182946.19; bar; bar-3; bar3; CG4637; Dmel\CG4637; hg; Hh; HH; l(3)hh; l(3)neo56; l(3)neo57; Mir; Mrt
Location:
94E1-94E1; 3-81.2 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.01 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23128169..23141906, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18953891..18967628, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Centaurin beta 1A Neighboring gene CG31365 gene product from transcript CG31365-RA Neighboring gene CG31457 gene product from transcript CG31457-RB Neighboring gene unkempt Neighboring gene Vacuolar H[+] ATPase AC39 subunit 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
cysteine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
endopeptidase activity NAS
Non-traceable Author Statement
more info
 
morphogen activity TAS
Traceable Author Statement
more info
PubMed 
patched binding NAS
Non-traceable Author Statement
more info
 
patched binding TAS
Traceable Author Statement
more info
PubMed 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Bolwig's organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
R8 cell fate specification NAS
Non-traceable Author Statement
more info
PubMed 
analia development TAS
Traceable Author Statement
more info
PubMed 
anterior commissure morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
anterior head segmentation TAS
Traceable Author Statement
more info
PubMed 
anterior/posterior axis specification, embryo NAS
Non-traceable Author Statement
more info
PubMed 
anterior/posterior lineage restriction, imaginal disc TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling IEA
Inferred from Electronic Annotation
more info
 
compartment pattern specification TAS
Traceable Author Statement
more info
PubMed 
compound eye morphogenesis TAS
Traceable Author Statement
more info
PubMed 
compound eye photoreceptor cell differentiation TAS
Traceable Author Statement
more info
PubMed 
cytoneme assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
developmental pigmentation TAS
Traceable Author Statement
more info
PubMed 
ectoderm development NAS
Non-traceable Author Statement
more info
PubMed 
embryonic pattern specification IEP
Inferred from Expression Pattern
more info
PubMed 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
epithelial cell migration, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
foregut morphogenesis TAS
Traceable Author Statement
more info
PubMed 
genital disc anterior/posterior pattern formation IEP
Inferred from Expression Pattern
more info
PubMed 
genital disc development IMP
Inferred from Mutant Phenotype
more info
PubMed 
genital disc development TAS
Traceable Author Statement
more info
PubMed 
germ cell attraction TAS
Traceable Author Statement
more info
PubMed 
germ cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ-line stem cell division TAS
Traceable Author Statement
more info
PubMed 
glial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
gonadal mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth NAS
Non-traceable Author Statement
more info
PubMed 
heart development NAS
Non-traceable Author Statement
more info
PubMed 
heart development TAS
Traceable Author Statement
more info
PubMed 
heart formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hindgut morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hindgut morphogenesis TAS
Traceable Author Statement
more info
PubMed 
imaginal disc growth TAS
Traceable Author Statement
more info
PubMed 
imaginal disc pattern formation NAS
Non-traceable Author Statement
more info
PubMed 
imaginal disc-derived wing vein specification TAS
Traceable Author Statement
more info
PubMed 
intein-mediated protein splicing IEA
Inferred from Electronic Annotation
more info
 
labial disc development IMP
Inferred from Mutant Phenotype
more info
PubMed 
leg disc morphogenesis TAS
Traceable Author Statement
more info
PubMed 
mesoderm development NAS
Non-traceable Author Statement
more info
PubMed 
morphogenesis of larval imaginal disc epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
open tracheal system development TAS
Traceable Author Statement
more info
PubMed 
ovarian follicle cell development TAS
Traceable Author Statement
more info
PubMed 
ovarian follicle cell stalk formation TAS
Traceable Author Statement
more info
PubMed 
pole cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hh target transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of smoothened signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of transcription factor import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
posterior head segmentation TAS
Traceable Author Statement
more info
PubMed 
progression of morphogenetic furrow involved in compound eye morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
progression of morphogenetic furrow involved in compound eye morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
progression of morphogenetic furrow involved in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
progression of morphogenetic furrow involved in compound eye morphogenesis TAS
Traceable Author Statement
more info
PubMed 
protein autoprocessing IDA
Inferred from Direct Assay
more info
PubMed 
protein autoprocessing IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autoprocessing NAS
Non-traceable Author Statement
more info
 
protein autoprocessing TAS
Traceable Author Statement
more info
 
protein splicing TAS
Traceable Author Statement
more info
 
regulation of cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of epithelial cell migration, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of organ growth TAS
Traceable Author Statement
more info
PubMed 
regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
segment polarity determination IEP
Inferred from Expression Pattern
more info
PubMed 
segment polarity determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
segment polarity determination NAS
Non-traceable Author Statement
more info
PubMed 
segment polarity determination TAS
Traceable Author Statement
more info
PubMed 
smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
smoothened signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
smoothened signaling pathway TAS
Traceable Author Statement
more info
PubMed 
somatic stem cell division TAS
Traceable Author Statement
more info
PubMed 
spiracle morphogenesis, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
trunk segmentation TAS
Traceable Author Statement
more info
PubMed 
ventral midline development IMP
Inferred from Mutant Phenotype
more info
PubMed 
wing disc anterior/posterior pattern formation TAS
Traceable Author Statement
more info
PubMed 
wing disc proximal/distal pattern formation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
 
cytoplasmic membrane-bounded vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
CG4637 gene product from transcript CG4637-RB
Names
CG4637-PB
bar-on-3
hedgehog
hedghog
hh-PB
mirabile
moonrat
NP_001034065.1

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 

    Range
    23128169..23141906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001038976.1NP_001034065.1  hedgehog [Drosophila melanogaster]

    See proteins identical to NP_001034065.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q02936
    Related
    FBpp0099945, FBtr0100506
    Conserved Domains (3) summary
    cd00081
    Location:258400
    Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
    pfam01079
    Location:254465
    Hint; Hint module
    pfam01085
    Location:99243
    HH_signal; Hedgehog amino-terminal signalling domain