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    VCAM1 vascular cell adhesion molecule 1 [ Homo sapiens (human) ]

    Gene ID: 7412, updated on 7-Feb-2016
    Official Symbol
    VCAM1provided by HGNC
    Official Full Name
    vascular cell adhesion molecule 1provided by HGNC
    Primary source
    HGNC:HGNC:12663
    See related
    Ensembl:ENSG00000162692; HPRD:01888; MIM:192225; Vega:OTTHUMG00000010982
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD106; INCAM-100
    Summary
    This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
    Orthologs
    See VCAM1 in Epigenomics, MapViewer
    Location:
    1p32-p31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (100719640..100739045)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (101185196..101204601)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1349 Neighboring gene ribosomal protein L36a pseudogene 12 Neighboring gene exostosin-like glycosyltransferase 2 Neighboring gene solute carrier family 30 (zinc transporter), member 7 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 68

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 activates human brain micro vascular endothelial cells (HBMEC) via CD4 in upregulating ICAM-1 and VCAM-1 expression, IL-6 secretion and increased monocyte transmigration across monolayers PubMed
    Tat tat HIV-1 Tat upregulates the expression of VCAM-1 in endothelial cells and astrocytes, an effect that is in part regulated by NF-kappa B and may be associated with AIDS-related Kaposi's sarcoma PubMed
    tat Cell-permeable SOD inhibits the activation of MAP kinases including ERK, JNK and p38 and the upregulation of ICAM-1 and VCAM-1 by HIV-1 Tat PubMed
    tat HIV-1 Tat-induced upregulation of VCAM-1/ICAM-1 is blocked by NADPH oxidase inhibitor PubMed
    Vpu vpu HIV-1 Vpu upregulates CD40 expression, which enhances efficient expression of VCAM-1 in endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
      AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
    • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
      AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
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    • African trypanosomiasis, organism-specific biosystem (from KEGG)
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    • African trypanosomiasis, conserved biosystem (from KEGG)
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    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
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    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
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    • Cellular roles of Anthrax toxin, organism-specific biosystem (from Pathway Interaction Database)
      Cellular roles of Anthrax toxin, organism-specific biosystem
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    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
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    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
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    • Interferon Signaling, organism-specific biosystem (from REACTOME)
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    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC99561, DKFZp779G2333

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cell adhesion molecule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integrin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    primary amine oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell differentiation IC
    Inferred by Curator
    more info
    PubMed 
    acute inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    amine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-mediated signaling using intracellular calcium source IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to vascular endothelial growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    chorio-allantoic fusion IEA
    Inferred from Electronic Annotation
    more info
     
    chronic inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    extracellular matrix organization TAS
    Traceable Author Statement
    more info
     
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    leukocyte cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukocyte tethering or rolling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukocyte tethering or rolling IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    membrane to membrane docking IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    response to zinc ion IEA
    Inferred from Electronic Annotation
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    podosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    vascular cell adhesion protein 1
    Names
    CD106 antigen

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023034.2 RefSeqGene

      Range
      4900..24305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001078.3NP_001069.1  vascular cell adhesion protein 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001069.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the predominant, full-length isoform (a).
      Source sequence(s)
      BC017276, BF791565, DB096825
      Consensus CDS
      CCDS773.1
      UniProtKB/Swiss-Prot
      P19320
      Related
      ENSP00000294728, OTTHUMP00000012650, ENST00000294728, OTTHUMT00000030213
      Conserved Domains (7) summary
      cd00096
      Location:530593
      Ig; Immunoglobulin domain
      cd07689
      Location:116214
      Ig2_VCAM-1; Second immunoglobulin (Ig)-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1, CD106) and intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
      smart00408
      Location:238298
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:609685
      IG; Immunoglobulin
      smart00410
      Location:33112
      IG_like; Immunoglobulin like
      pfam07679
      Location:313399
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:604685
      Ig; Immunoglobulin domain
    2. NM_001199834.1NP_001186763.1  vascular cell adhesion protein 1 isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame segment in the CDS compared to transcript variant 1. The resulting isoform (c) lacks an internal segment compared to isoform a.
      Source sequence(s)
      AK296692, BC017276, BF968655, DB096825
      Consensus CDS
      CCDS55617.1
      UniProtKB/Swiss-Prot
      P19320
      Related
      ENSP00000359137, OTTHUMP00000038305, ENST00000370119, OTTHUMT00000097431
      Conserved Domains (5) summary
      cd00096
      Location:468531
      Ig; Immunoglobulin domain
      cd07689
      Location:54152
      Ig2_VCAM-1; Second immunoglobulin (Ig)-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1, CD106) and intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
      smart00408
      Location:176236
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:259337
      IG_like; Immunoglobulin like
      cl11960
      Location:542623
      Ig; Immunoglobulin domain
    3. NM_080682.2NP_542413.1  vascular cell adhesion protein 1 isoform b precursor

      See identical proteins and their annotated locations for NP_542413.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the CDS compared to transcript variant 1. The resulting isoform (b) lacks an internal segment compared to isoform a.
      Source sequence(s)
      BC017276, BF791565, DB096825, M30257
      Consensus CDS
      CCDS774.1
      UniProtKB/Swiss-Prot
      P19320
      Related
      ENSP00000304611, OTTHUMP00000012651, ENST00000347652, OTTHUMT00000030214
      Conserved Domains (5) summary
      cd00096
      Location:438501
      Ig; Immunoglobulin domain
      cd07689
      Location:116214
      Ig2_VCAM-1; Second immunoglobulin (Ig)-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1, CD106) and intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
      smart00408
      Location:238298
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:33112
      IG_like; Immunoglobulin like
      cl11960
      Location:512593
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

      Range
      100719640..100739045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      101301307..101320707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)