Display Settings:

Format

Send to:

Choose Destination

TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) [ Homo sapiens (human) ]

Gene ID: 6934, updated on 11-Sep-2014
Official Symbol
TCF7L2provided by HGNC
Official Full Name
transcription factor 7-like 2 (T-cell specific, HMG-box)provided by HGNC
Primary source
HGNC:HGNC:11641
Locus tag
RP11-357H24.1
See related
Ensembl:ENSG00000148737; HPRD:03751; MIM:602228; Vega:OTTHUMG00000019070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCF4; TCF-4
Summary
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
Annotation information
Note: TCF4 (GeneID: 6925) and TCF7L2 (GeneID: 6934) loci share the TCF4 symbol/alias in common. TCF4 is a widely used alternative name for T-cell-specific transcription factor 4 (TCF7L2) conflicting with the official symbol for transcription factor 4 (TCF4). [26 Jun 2008]
See TCF7L2 in Epigenomics, MapViewer
Location:
10q25.3
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (112950219..113167678)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (114709978..114927437)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene microRNA 4295 Neighboring gene uncharacterized LOC102724518 Neighboring gene ribosomal protein S15a pseudogene 30 Neighboring gene peptidyl-prolyl cis-trans isomerase A-like Neighboring gene hyaluronan binding protein 2 Neighboring gene nebulin-related anchoring protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Diabetes mellitus type 2
MedGen: C0011860 OMIM: 125853 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
NHGRI GWA Catalog
A genome-wide association study identifies novel risk loci for type 2 diabetes.
NHGRI GWA Catalog
A genome-wide association study of the metabolic syndrome in Indian Asian men.
NHGRI GWA Catalog
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
NHGRI GWA Catalog
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
NHGRI GWA Catalog
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
NHGRI GWA Catalog
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
NHGRI GWA Catalog
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
NHGRI GWA Catalog
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
NHGRI GWA Catalog
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
NHGRI GWA Catalog
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
NHGRI GWA Catalog
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.
NHGRI GWA Catalog
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
NHGRI GWA Catalog
Genome-wide association study identifies three novel loci for type 2 diabetes.
NHGRI GWA Catalog
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
NHGRI GWA Catalog
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
NHGRI GWA Catalog
Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.
NHGRI GWA Catalog
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
NHGRI GWA Catalog
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
NHGRI GWA Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
NHGRI GWA Catalog
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
NHGRI GWA Catalog
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
NHGRI GWA Catalog
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
NHGRI GWA Catalog
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
NHGRI GWA Catalog
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
NHGRI GWA Catalog
The TCF7L2 diabetes risk variant is associated with HbA₁(C) levels: a genome-wide association meta-analysis.
NHGRI GWA Catalog
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
NHGRI GWA Catalog
Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.
NHGRI GWA Catalog
Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of TCF-4 in human astrocytic cells decreased HIV-1 Tat-mediated transcription of the HIV-1 LTR, while GST pull-down assays revealed a direct interaction of Tat with TCF-4, suggesting TCF-4 may regulate the level of HIV-1 gene transcription PubMed

Go to the HIV-1, Human Protein Interaction Database

  • AMER1 mutants destabilize the destruction complex, organism-specific biosystem (from REACTOME)
    AMER1 mutants destabilize the destruction complex, organism-specific biosystemAMER1/WTX is a component of the destruction complex that interacts directly with beta-catenin through its C-terminal half. Depletion of AMER1 through siRNA stabilizes cellular beta-catenin levels an...
  • APC truncation mutants are not K63 polyubiquitinated, organism-specific biosystem (from REACTOME)
    APC truncation mutants are not K63 polyubiquitinated, organism-specific biosystemAPC has been shown to be reversibly modified with K63-linked polyubiquitin chains. This modification is required for the association is required for the assembly of the destruction complex and subse...
  • APC truncation mutants have impaired AXIN binding, organism-specific biosystem (from REACTOME)
    APC truncation mutants have impaired AXIN binding, organism-specific biosystemMutations in the APC tumor suppressor gene are common in colorectal and other cancers and cluster in the central mutation cluster region (MCR) of the gene (Miyoshi et al, 1992; Nagase and Nakamura, ...
  • AXIN missense mutants destabilize the destruction complex, organism-specific biosystem (from REACTOME)
    AXIN missense mutants destabilize the destruction complex, organism-specific biosystemAlterations in AXIN1 have been detected in a number of different cancers including liver and colorectal cancer and medullablastoma, among others (reviewed in Salahshor and Woodgett, 2005). Missense ...
  • AXIN mutants destabilize the destruction complex, activating WNT signaling, organism-specific biosystem (from REACTOME)
    AXIN mutants destabilize the destruction complex, activating WNT signaling, organism-specific biosystemAXIN1 and AXIN2 are critical scaffolding proteins of the beta-catenin destruction complex and make protein-protein interactions with several of the other complex components including APC, GSK3, CK1 a...
  • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
    Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
  • Acute myeloid leukemia, conserved biosystem (from KEGG)
    Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
  • Adherens junction, organism-specific biosystem (from KEGG)
    Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Adherens junction, conserved biosystem (from KEGG)
    Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Arrhythmogenic right ventricular cardiomyopathy, organism-specific biosystem (from WikiPathways)
    Arrhythmogenic right ventricular cardiomyopathy, organism-specific biosystemAdapted from KEGG: http://www.genome.jp/kegg/pathway/hsa/hsa05412.html
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Basal cell carcinoma, organism-specific biosystem (from KEGG)
    Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Basal cell carcinoma, conserved biosystem (from KEGG)
    Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Ca2+ pathway, organism-specific biosystem (from REACTOME)
    Ca2+ pathway, organism-specific biosystemA number of so called non-canonical WNT ligands have been shown to promote intracellular calcium release upon FZD binding. This beta-catenin-independent WNT pathway acts through heterotrimeric G pro...
  • Colorectal cancer, organism-specific biosystem (from KEGG)
    Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • Colorectal cancer, conserved biosystem (from KEGG)
    Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
    Degradation of beta-catenin by the destruction complex, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Endometrial cancer, organism-specific biosystem (from KEGG)
    Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
  • Endometrial cancer, conserved biosystem (from KEGG)
    Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
  • Incretin synthesis, secretion, and inactivation, organism-specific biosystem (from REACTOME)
    Incretin synthesis, secretion, and inactivation, organism-specific biosystemIncretins are peptide hormones produced by the gut that enhance the ability of glucose to stimulate insulin secretion from beta cells in the pancreas. Two incretins have been identified: Glucagon-lik...
  • Melanogenesis, organism-specific biosystem (from KEGG)
    Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Melanogenesis, conserved biosystem (from KEGG)
    Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
    Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
  • Prostate cancer, organism-specific biosystem (from KEGG)
    Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
  • Prostate cancer, conserved biosystem (from KEGG)
    Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
  • RNF mutants show enhanced WNT signaling and proliferation, organism-specific biosystem (from REACTOME)
    RNF mutants show enhanced WNT signaling and proliferation, organism-specific biosystemRNF43 and related protein ZNRF3 are E3 ubiquitin ligases that negatively regulate WNT signaling by downregulating FZD receptors at the cell surface (Mukai et al, 2010; Hao et al, 2012). Frameshift l...
  • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
  • S33 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
    S33 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemS33 mutations of beta-catenin interfere with GSK3 phosphorylation and result in stabilization and nuclear localization of the protein and enhanced WNT signaling (Groen et al, 2008; Nhieu et al, 1999;...
  • S37 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
    S37 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemS37 mutations of beta-catenin interfere with GSK3 phosphorylation and stabilize the protein, resulting in enhanced WNT pathway signaling (Nhieu et al, 1999; Clements et al, 2002; reviewed in Polakis,...
  • S45 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
    S45 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemS45 mutants of beta-catenin have been identified in colorectal and hepatocellular carcinomas, soft tissue cancer and Wilms Tumors, among others (reviewed in Polakis, 2000). These mutations abolish th...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by WNT in cancer, organism-specific biosystem (from REACTOME)
    Signaling by WNT in cancer, organism-specific biosystemThe WNT signaling pathway has been linked with cancer ever since the identification of the first WNT as a gene activated by integration of mouse mammary tumor virus proviral DNA in virally-induced br...
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
  • Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystem (from REACTOME)
    Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystemIn L cells of the intestine the transcription factors TCF-4 (TCF7L2) and Beta-catenin form a heterodimer and bind the G2 enhancer of the Proglucagon gene GCG,activating its transcription to yield Pro...
  • T41 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
    T41 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemT41 mutations of beta-catenin interfere with GSK3 phosphorylation and result in stabilization and nuclear accumulation of the protein (Moreno-Bueno et al, 2002; Taniguchi et al, 2002; reviewed in Pol...
  • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
    TCF dependent signaling in response to WNT, organism-specific biosystem19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of ...
  • TCF7L2 mutants don't bind CTBP, organism-specific biosystem (from REACTOME)
    TCF7L2 mutants don't bind CTBP, organism-specific biosystem~50% of colorectal cancers with microsatellite instability show frameshift mutations in TCF7L2 that result in the loss of the CTBP-binding region (Duval et al, 1999; Cuillliere-Dartigues et al, 2006)...
  • Thyroid cancer, organism-specific biosystem (from KEGG)
    Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
  • Thyroid cancer, conserved biosystem (from KEGG)
    Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • XAV939 inhibits tankyrase, stabilizing AXIN, organism-specific biosystem (from REACTOME)
    XAV939 inhibits tankyrase, stabilizing AXIN, organism-specific biosystemXAV939 binds to the catalytic sites of tankyrase 1 and 2 and inhibits the ADP-ribosylation of AXIN1 and 2. Treatment of cells with XAV939 significantly increases the protein, but not the mRNA levels ...
  • beta-catenin independent WNT signaling, organism-specific biosystem (from REACTOME)
    beta-catenin independent WNT signaling, organism-specific biosystemHumans and mice have 19 identified WNT proteins that were originally classified as either 'canonical' or 'non-canonical' depending upon whether they were able to transform the mouse mammary epithelia...
  • binding of TCF/LEF:CTNNB1 to target gene promoters, organism-specific biosystem (from REACTOME)
    binding of TCF/LEF:CTNNB1 to target gene promoters, organism-specific biosystemThe genes regulated by beta-catenin and TCF/LEF are involved in a diverse range of functions in cellular proliferation, differentiation, embryogenesis and tissue homeostasis, and include transcriptio...
  • deactivation of the beta-catenin transactivating complex, organism-specific biosystem (from REACTOME)
    deactivation of the beta-catenin transactivating complex, organism-specific biosystemThe mechanisms involved in downregulation of TCF-dependent transcription are not yet very well understood. beta-catenin is known to recruit a number of transcriptional repressors, including Reptin, S...
  • deletions in the AMER1 gene destabilize the destruction complex, organism-specific biosystem (from REACTOME)
    deletions in the AMER1 gene destabilize the destruction complex, organism-specific biosystemGenomic deletions of the entire AMER1/WTX gene occur in about 12% of Wilms tumors, a pediatric kidney cancer. Nonsense and missense mutations have also been identified (Ruteshouser et al, 2008; Wege...
  • deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling, organism-specific biosystem (from REACTOME)
    deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling, organism-specific biosystemDeletions in the AXIN1 gene have been identified in 2 hepatocellular carcinoma cell lines. These deletions, which remove the N-terminal exons of the gene, compromise AXIN1 expression and result in ...
  • formation of the beta-catenin:TCF transactivating complex, organism-specific biosystem (from REACTOME)
    formation of the beta-catenin:TCF transactivating complex, organism-specific biosystemOnce in the nucleus, beta-catenin is recruited to WNT target genes through interaction with TCF/LEF transcription factors. This family, which consists of TCF7 (also known as TCF1), TCF7L1 (also known...
  • misspliced GSK3beta mutants stabilize beta-catenin, organism-specific biosystem (from REACTOME)
    misspliced GSK3beta mutants stabilize beta-catenin, organism-specific biosystemGSK3beta is subject to in-frame missplicing in CML stem cells resulting in the production of mutant protein that lacks the AXIN and FRAT binding domains. Cells containing this mutant GSK3beta show e...
  • misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling, organism-specific biosystem (from REACTOME)
    misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling, organism-specific biosystemLRP5 is subject to an in-frame missplicing event in breast and parathyroid cancers that renders the protein insensitive to inhibition by the WNT antagonist DKK1. Expression of the mutant protein res...
  • phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex, organism-specific biosystem (from REACTOME)
    phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex, organism-specific biosystemMutations in exon 3 of the beta-catenin gene have been identified in a number of human cancers (Morin et al, 1997; Rubinfeld et al, 1997; reviewed in Polakis, 2000; Polakis, 2007). These mutations g...
  • repression of WNT target genes, organism-specific biosystem (from REACTOME)
    repression of WNT target genes, organism-specific biosystemIn the absence of a WNT signal, many WNT target genes are repressed by Groucho/TLE. Groucho was initially identified in Drosophila, where it has been shown to interact with a variety of proteins to ...
  • truncated APC mutants destabilize the destruction complex, organism-specific biosystem (from REACTOME)
    truncated APC mutants destabilize the destruction complex, organism-specific biosystemAPC is a large and central component of the destruction complex, which limits signaling in the absence of WNT ligand by promoting the ubiquitin-mediated degradation of beta-catenin. APC interacts wi...
  • truncations of AMER1 destabilize the destruction complex, organism-specific biosystem (from REACTOME)
    truncations of AMER1 destabilize the destruction complex, organism-specific biosystemAMER1/WTX is a known component of the destruction complex and interacts directly with beta-catenin through the C-terminal half (Major et al, 2007). siRNA depletion of AMER1 in mammalian cells stabil...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
armadillo repeat domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
gamma-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
 
Process Evidence Code Pubs
blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone mineralization IEA
Inferred from Electronic Annotation
more info
 
brain development IBA
Inferred from Biological aspect of Ancestor
more info
 
canonical Wnt signaling pathway IC
Inferred by Curator
more info
PubMed 
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
catenin import into nucleus IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to starvation IEA
Inferred from Electronic Annotation
more info
 
embryonic digestive tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic genitalia morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic hindgut morphogenesis IEA
Inferred from Electronic Annotation
more info
 
face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
generation of neurons IBA
Inferred from Biological aspect of Ancestor
more info
 
glucose homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
insulin metabolic process IEA
Inferred from Electronic Annotation
more info
 
maintenance of DNA repeat elements IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
myoblast fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of type B pancreatic cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
neural tube development IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
oligodendrocyte development IEA
Inferred from Electronic Annotation
more info
 
pancreas development TAS
Traceable Author Statement
more info
PubMed 
pituitary gland development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heparan sulfate proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
regulation of hormone metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
regulation of myelination IEA
Inferred from Electronic Annotation
more info
 
regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
response to glucose ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
secretory granule localization IEA
Inferred from Electronic Annotation
more info
 
skin development IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell maintenance IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body IEA
Inferred from Electronic Annotation
more info
 
beta-catenin-TCF7L2 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
transcription factor 7-like 2
Names
transcription factor 7-like 2
hTCF-4
T-cell factor 4
T-cell factor-4 variant A
T-cell factor-4 variant B
T-cell factor-4 variant C
T-cell factor-4 variant D
T-cell factor-4 variant E
T-cell factor-4 variant F
T-cell factor-4 variant G
T-cell factor-4 variant H
T-cell factor-4 variant I
T-cell factor-4 variant J
T-cell factor-4 variant K
T-cell factor-4 variant L
T-cell factor-4 variant M
T-cell factor-4 variant X2
HMG box transcription factor 4
T-cell-specific transcription factor 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012631.1 

    Range
    5001..222429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001146274.1NP_001139746.1  transcription factor 7-like 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform.
    Source sequence(s)
    AL158212, AL445486, AL451084
    UniProtKB/Swiss-Prot
    Q9NQB0
    Conserved Domains (2) summary
    cd01388
    Location:353420
    Blast Score: 325
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    Blast Score: 612
    CTNNB1_binding; N-terminal CTNNB1 binding
  2. NM_001146283.1NP_001139755.1  transcription factor 7-like 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL135792, AL158212, AL445486, AL451084
    Consensus CDS
    CCDS53578.1
    UniProtKB/Swiss-Prot
    Q9NQB0
    Related
    ENSP00000347949, ENST00000355717
    Conserved Domains (2) summary
    cd01388
    Location:377444
    Blast Score: 320
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1283
    Blast Score: 600
    CTNNB1_binding; N-terminal CTNNB1 binding
  3. NM_001146284.1NP_001139756.1  transcription factor 7-like 2 isoform 4

    See proteins identical to NP_001139756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL158212, AL445486, AL451084
    UniProtKB/Swiss-Prot
    Q9NQB0
    Conserved Domains (2) summary
    cd01388
    Location:326393
    Blast Score: 319
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    Blast Score: 639
    CTNNB1_binding; N-terminal CTNNB1 binding
  4. NM_001146285.1NP_001139757.1  transcription factor 7-like 2 isoform 5

    See proteins identical to NP_001139757.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 5, which is shorter than isoform 1.
    Source sequence(s)
    AL158212, AL445486, AL451084
    Consensus CDS
    CCDS73197.1
    UniProtKB/TrEMBL
    C6ZRK5
    Related
    ENSP00000446238, ENST00000536810
    Conserved Domains (2) summary
    cd01388
    Location:330397
    Blast Score: 325
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    Blast Score: 626
    CTNNB1_binding; N-terminal CTNNB1 binding
  5. NM_001146286.1NP_001139758.1  transcription factor 7-like 2 isoform 6

    See proteins identical to NP_001139758.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 6) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL158212, AL445486, AL451084
    UniProtKB/Swiss-Prot
    Q9NQB0
    Conserved Domains (2) summary
    cd01388
    Location:330397
    Blast Score: 318
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    Blast Score: 638
    CTNNB1_binding; N-terminal CTNNB1 binding
  6. NM_001198525.1NP_001185454.1  transcription factor 7-like 2 isoform 7

    See proteins identical to NP_001185454.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 7) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL451084, DA473655, FJ010166, FJ010170
    Consensus CDS
    CCDS73196.1
    UniProtKB/TrEMBL
    C6ZRJ7
    UniProtKB/TrEMBL
    C6ZRK1
    Related
    ENSP00000440547, ENST00000545257
    Conserved Domains (2) summary
    cd01388
    Location:335402
    Blast Score: 322
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    Blast Score: 650
    CTNNB1_binding; N-terminal CTNNB1 binding
  7. NM_001198526.1NP_001185455.1  transcription factor 7-like 2 isoform 8

    See proteins identical to NP_001185455.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 8, which is shorter than isoform 1.
    Source sequence(s)
    AL451084, DA473655, FJ010167
    UniProtKB/Swiss-Prot
    Q9NQB0
    Conserved Domains (2) summary
    cd01388
    Location:330397
    Blast Score: 325
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    Blast Score: 630
    CTNNB1_binding; N-terminal CTNNB1 binding
  8. NM_001198527.1NP_001185456.1  transcription factor 7-like 2 isoform 9

    See proteins identical to NP_001185456.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 9) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL451084, DA473655, FJ010168
    UniProtKB/TrEMBL
    C6ZRJ9
    Conserved Domains (2) summary
    cd01388
    Location:326393
    Blast Score: 322
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    Blast Score: 642
    CTNNB1_binding; N-terminal CTNNB1 binding
  9. NM_001198528.1NP_001185457.1  transcription factor 7-like 2 isoform 10

    See proteins identical to NP_001185457.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 10) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL451084, DA473655, FJ010169
    Consensus CDS
    CCDS55729.1
    UniProtKB/Swiss-Prot
    Q9NQB0
    Related
    ENSP00000344823, ENST00000352065
    Conserved Domains (2) summary
    cd01388
    Location:330397
    Blast Score: 322
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    Blast Score: 642
    CTNNB1_binding; N-terminal CTNNB1 binding
  10. NM_001198529.1NP_001185458.1  transcription factor 7-like 2 isoform 11

    See proteins identical to NP_001185458.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 11) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL451084, DA473655, FJ010170
    UniProtKB/TrEMBL
    C6ZRK1
    Conserved Domains (2) summary
    cd01388
    Location:330397
    Blast Score: 320
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    Blast Score: 639
    CTNNB1_binding; N-terminal CTNNB1 binding
  11. NM_001198530.1NP_001185459.1  transcription factor 7-like 2 isoform 12

    See proteins identical to NP_001185459.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 12) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL451084, DA473655, FJ010171
    Consensus CDS
    CCDS73198.1
    UniProtKB/TrEMBL
    C6ZRK2
    Related
    ENSP00000443626, ENST00000534894
    Conserved Domains (2) summary
    cd01388
    Location:296363
    Blast Score: 319
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1202
    Blast Score: 676
    CTNNB1_binding; N-terminal CTNNB1 binding
  12. NM_001198531.1NP_001185460.1  transcription factor 7-like 2 isoform 13

    See proteins identical to NP_001185460.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 13) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB440195, AL451084, DA473655
    UniProtKB/Swiss-Prot
    Q9NQB0
    Conserved Domains (2) summary
    cd01388
    Location:353420
    Blast Score: 318
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    Blast Score: 621
    CTNNB1_binding; N-terminal CTNNB1 binding
  13. NM_030756.4NP_110383.2  transcription factor 7-like 2 isoform 2

    See proteins identical to NP_110383.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL158212, AL445486, AL451084
    Consensus CDS
    CCDS7576.1
    UniProtKB/TrEMBL
    Q6FHW4
    Related
    ENSP00000358404, OTTHUMP00000020496, ENST00000369397, OTTHUMT00000050413
    Conserved Domains (2) summary
    cd01388
    Location:330397
    Blast Score: 326
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    Blast Score: 627
    CTNNB1_binding; N-terminal CTNNB1 binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    112950219..113167678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270071.1XP_005270128.1  

    Conserved Domains (2) summary
    cd01388
    Location:406473
    Blast Score: 327
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    Blast Score: 569
    CTNNB1_binding; N-terminal CTNNB1 binding
  2. XM_005270093.1XP_005270150.1  

    Conserved Domains (2) summary
    cd01388
    Location:406473
    Blast Score: 322
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    Blast Score: 581
    CTNNB1_binding; N-terminal CTNNB1 binding
  3. XM_005270077.1XP_005270134.1  

    Conserved Domains (2) summary
    cd01388
    Location:406473
    Blast Score: 326
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    Blast Score: 568
    CTNNB1_binding; N-terminal CTNNB1 binding
  4. XM_005270078.1XP_005270135.1  

    Conserved Domains (2) summary
    cd01388
    Location:406473
    Blast Score: 326
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    Blast Score: 571
    CTNNB1_binding; N-terminal CTNNB1 binding
  5. XM_005270095.1XP_005270152.1  

    Conserved Domains (2) summary
    cd01388
    Location:406473
    Blast Score: 321
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    Blast Score: 581
    CTNNB1_binding; N-terminal CTNNB1 binding
  6. XM_005270075.1XP_005270132.1  

    Conserved Domains (2) summary
    cd01388
    Location:401468
    Blast Score: 327
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    Blast Score: 569
    CTNNB1_binding; N-terminal CTNNB1 binding
  7. XM_005270079.1XP_005270136.1  

    Conserved Domains (2) summary
    cd01388
    Location:401468
    Blast Score: 326
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    Blast Score: 568
    CTNNB1_binding; N-terminal CTNNB1 binding
  8. XM_005270074.1XP_005270131.1  

    Conserved Domains (3) summary
    cd01388
    Location:402469
    Blast Score: 327
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam03153
    Location:211376
    Blast Score: 88
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam08347
    Location:1307
    Blast Score: 569
    CTNNB1_binding; N-terminal CTNNB1 binding
  9. XM_005270076.1XP_005270133.1  

    Conserved Domains (2) summary
    cd01388
    Location:397464
    Blast Score: 326
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    Blast Score: 569
    CTNNB1_binding; N-terminal CTNNB1 binding
  10. XM_005270073.1XP_005270130.1  

    Conserved Domains (2) summary
    cd01388
    Location:405472
    Blast Score: 327
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1306
    Blast Score: 570
    CTNNB1_binding; N-terminal CTNNB1 binding
  11. XM_005270094.1XP_005270151.1  

    Conserved Domains (2) summary
    cd01388
    Location:405472
    Blast Score: 322
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1306
    Blast Score: 582
    CTNNB1_binding; N-terminal CTNNB1 binding
  12. XM_005270082.1XP_005270139.1  

    Conserved Domains (2) summary
    cd01388
    Location:358425
    Blast Score: 327
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    Blast Score: 610
    CTNNB1_binding; N-terminal CTNNB1 binding
  13. XM_005270085.1XP_005270142.1  

    See proteins identical to XP_005270142.1

    UniProtKB/TrEMBL
    E2GH26
    Related
    ENSP00000444972, ENST00000543371
    Conserved Domains (2) summary
    cd01388
    Location:358425
    Blast Score: 325
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    Blast Score: 612
    CTNNB1_binding; N-terminal CTNNB1 binding
  14. XM_005270100.1XP_005270157.1  

    See proteins identical to XP_005270157.1

    UniProtKB/TrEMBL
    E2GH16
    Conserved Domains (2) summary
    cd01388
    Location:358425
    Blast Score: 319
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    Blast Score: 621
    CTNNB1_binding; N-terminal CTNNB1 binding
  15. XM_005270084.1XP_005270141.1  

    See proteins identical to XP_005270141.1

    UniProtKB/Swiss-Prot
    Q9NQB0
    Related
    ENSP00000348274, ENST00000355995
    Conserved Domains (2) summary
    cd01388
    Location:353420
    Blast Score: 326
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    Blast Score: 610
    CTNNB1_binding; N-terminal CTNNB1 binding
  16. XM_005270096.1XP_005270153.1  

    See proteins identical to XP_005270153.1

    UniProtKB/Swiss-Prot
    Q9NQB0
    Related
    ENSP00000446172, ENST00000538897
    Conserved Domains (2) summary
    cd01388
    Location:353420
    Blast Score: 320
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    Blast Score: 622
    CTNNB1_binding; N-terminal CTNNB1 binding
  17. XM_005270083.1XP_005270140.1  

    Conserved Domains (2) summary
    cd01388
    Location:354421
    Blast Score: 327
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    Blast Score: 610
    CTNNB1_binding; N-terminal CTNNB1 binding
  18. XM_005270102.1XP_005270159.1  

    Conserved Domains (2) summary
    cd01388
    Location:349416
    Blast Score: 318
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1259
    Blast Score: 622
    CTNNB1_binding; N-terminal CTNNB1 binding
  19. XM_005270080.1XP_005270137.1  

    Conserved Domains (2) summary
    cd01388
    Location:383450
    Blast Score: 327
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1284
    Blast Score: 587
    CTNNB1_binding; N-terminal CTNNB1 binding
  20. XM_006717955.1XP_006718018.1  

    Conserved Domains (2) summary
    cd01388
    Location:374441
    Blast Score: 327
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1284
    Blast Score: 587
    CTNNB1_binding; N-terminal CTNNB1 binding
  21. XM_005270086.1XP_005270143.1  

    See proteins identical to XP_005270143.1

    Conserved Domains (2) summary
    cd01388
    Location:335402
    Blast Score: 327
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    Blast Score: 627
    CTNNB1_binding; N-terminal CTNNB1 binding
  22. XM_005270101.1XP_005270158.1  

    See proteins identical to XP_005270158.1

    UniProtKB/TrEMBL
    E2GH13
    Conserved Domains (2) summary
    cd01388
    Location:335402
    Blast Score: 321
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    Blast Score: 639
    CTNNB1_binding; N-terminal CTNNB1 binding
  23. XM_005270089.1XP_005270146.1  

    See proteins identical to XP_005270146.1

    UniProtKB/Swiss-Prot
    Q9NQB0
    Conserved Domains (2) summary
    cd01388
    Location:335402
    Blast Score: 326
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    Blast Score: 630
    CTNNB1_binding; N-terminal CTNNB1 binding
  24. XM_005270103.1XP_005270160.1  

    See proteins identical to XP_005270160.1

    UniProtKB/Swiss-Prot
    Q9NQB0
    Conserved Domains (2) summary
    cd01388
    Location:335402
    Blast Score: 319
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    Blast Score: 638
    CTNNB1_binding; N-terminal CTNNB1 binding
  25. XM_005270088.1XP_005270145.1  

    See proteins identical to XP_005270145.1

    Conserved Domains (2) summary
    cd01388
    Location:326393
    Blast Score: 326
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    Blast Score: 628
    CTNNB1_binding; N-terminal CTNNB1 binding
  26. XM_005270104.1XP_005270161.1  

    See proteins identical to XP_005270161.1

    UniProtKB/TrEMBL
    E2GH18
    Conserved Domains (2) summary
    cd01388
    Location:326393
    Blast Score: 317
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1236
    Blast Score: 638
    CTNNB1_binding; N-terminal CTNNB1 binding
  27. XM_005270091.1XP_005270148.1  

    See proteins identical to XP_005270148.1

    Conserved Domains (2) summary
    cd01388
    Location:406473
    Blast Score: 323
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    Blast Score: 590
    CTNNB1_binding; N-terminal CTNNB1 binding
  28. XM_005270092.1XP_005270149.1  

    See proteins identical to XP_005270149.1

    Conserved Domains (2) summary
    cd01388
    Location:406473
    Blast Score: 323
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1307
    Blast Score: 590
    CTNNB1_binding; N-terminal CTNNB1 binding
  29. XM_006717956.1XP_006718019.1  

    Conserved Domains (2) summary
    cd01388
    Location:253320
    Blast Score: 328
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:75154
    Blast Score: 345
    CTNNB1_binding; N-terminal CTNNB1 binding
  30. XM_006717957.1XP_006718020.1  

    Conserved Domains (2) summary
    cd01388
    Location:175242
    Blast Score: 328
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:276
    Blast Score: 337
    CTNNB1_binding; N-terminal CTNNB1 binding
  31. XM_006717958.1XP_006718021.1  

    Conserved Domains (2) summary
    cd01388
    Location:170237
    Blast Score: 328
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:276
    Blast Score: 337
    CTNNB1_binding; N-terminal CTNNB1 binding
  32. XM_005270097.2XP_005270154.1  

    Conserved Domains (2) summary
    cd01388
    Location:215282
    Blast Score: 328
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:42116
    Blast Score: 347
    CTNNB1_binding; N-terminal CTNNB1 binding
  33. XM_005270099.2XP_005270156.1  

    Conserved Domains (3) summary
    cd01388
    Location:210277
    Blast Score: 328
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam03153
    Location:46189
    Blast Score: 85
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam08347
    Location:42116
    Blast Score: 347
    CTNNB1_binding; N-terminal CTNNB1 binding
  34. XM_005270098.2XP_005270155.1  

    Conserved Domains (2) summary
    cd01388
    Location:211278
    Blast Score: 328
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:42116
    Blast Score: 347
    CTNNB1_binding; N-terminal CTNNB1 binding
  35. XM_005270105.2XP_005270162.1  

    See proteins identical to XP_005270162.1

    UniProtKB/TrEMBL
    B4DJZ2
    Conserved Domains (3) summary
    cd01388
    Location:210277
    Blast Score: 327
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam03153
    Location:46189
    Blast Score: 88
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam08347
    Location:42116
    Blast Score: 359
    CTNNB1_binding; N-terminal CTNNB1 binding

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    108337509..108554907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    114992047..115209474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)