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Cxcl12 chemokine (C-X-C motif) ligand 12 [ Mus musculus (house mouse) ]

Gene ID: 20315, updated on 17-May-2015
Official Symbol
Cxcl12provided by MGI
Official Full Name
chemokine (C-X-C motif) ligand 12provided by MGI
Primary source
MGI:MGI:103556
See related
Ensembl:ENSMUSG00000061353; Vega:OTTMUSG00000022768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pbsf; Sdf1; Tlsf; Tpar1; Scyb12
Summary
This gene encodes a member of the alpha chemokine protein family. The encoded protein is secreted and functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4. The encoded protein plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Orthologs
See Cxcl12 in MapViewer
Location:
6 54.81 cM; 6 F1
Exon count:
4
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (117168535..117181368)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (117118553..117131386)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36873 Neighboring gene uncharacterized LOC102631679 Neighboring gene ribosomal protein L28, pseudogene 4 Neighboring gene predicted gene 6227

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
CXCR chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
chemokine activity ISO
Inferred from Sequence Orthology
more info
 
chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
ameboidal-type cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain development IDA
Inferred from Direct Assay
more info
PubMed 
cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
chemokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
germ cell development IDA
Inferred from Direct Assay
more info
PubMed 
germ cell migration IDA
Inferred from Direct Assay
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
induction of positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
negative regulation of leukocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
organ regeneration ISO
Inferred from Sequence Orthology
more info
 
patterning of blood vessels IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of myoblast fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
telencephalon cell migration ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
stromal cell-derived factor 1
Names
stromal cell-derived factor 1
12-O-tetradecanoylphorbol 13-acetate repressed protein 1
pre-B-cell growth-stimulating factor
thymic lymphoma cell-stimulating factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012477.2NP_001012495.1  stromal cell-derived factor 1 isoform gamma precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (gamma).
    Source sequence(s)
    AC155646, BC046827
    Consensus CDS
    CCDS20463.1
    UniProtKB/TrEMBL
    H7BX38
    Related
    ENSMUSP00000072800, OTTMUSP00000026114, ENSMUST00000073043, OTTMUST00000054664
    Conserved Domains (1) summary
    cd00273
    Location:2788
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...
  2. NM_013655.4NP_038683.1  stromal cell-derived factor 1 isoform beta precursor

    See identical proteins and their annotated locations for NP_038683.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 3. The resulting isoform (beta) is shorter and has a distinct C-terminus compared to isoform gamma.
    Source sequence(s)
    AC155646, BB840704
    Consensus CDS
    CCDS39605.1
    UniProtKB/Swiss-Prot
    P40224
    Related
    ENSMUSP00000108492, OTTMUSP00000026113, ENSMUST00000112871, OTTMUST00000054663
    Conserved Domains (1) summary
    cd00273
    Location:2788
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...
  3. NM_021704.3NP_068350.1  stromal cell-derived factor 1 isoform alpha precursor

    See identical proteins and their annotated locations for NP_068350.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR and 3' coding region compared to variant 3. The resulting isoform (alpha) is shorter at the C-terminus, compared to isoform gamma.
    Source sequence(s)
    AC155646, AK045092
    Consensus CDS
    CCDS39606.1
    UniProtKB/Swiss-Prot
    P40224
    Related
    ENSMUSP00000108487, OTTMUSP00000026112, ENSMUST00000112866, OTTMUST00000054662
    Conserved Domains (1) summary
    cd00273
    Location:2788
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    117168535..117181368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    118991272..119004105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)