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Sav1 salvador homolog 1 (Drosophila) [ Mus musculus (house mouse) ]

Gene ID: 64010, updated on 8-Dec-2014
Official Symbol
Sav1provided by MGI
Official Full Name
salvador homolog 1 (Drosophila)provided by MGI
Primary source
MGI:MGI:1927144
See related
Ensembl:ENSMUSG00000021067
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sav; Salv; WW45; Wwp3; Wwp4; 1700040G09Rik
See Sav1 in Epigenomics
Location:
12; 12 C3
Exon count:
5
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 12 NC_000078.6 (69965012..69987002, complement)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene atlastin GTPase 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 31827 Neighboring gene RuvB-like protein 1 pseudogene Neighboring gene predicted gene, 31918 Neighboring gene synaptotagmin binding, cytoplasmic RNA interacting protein pseudogene Neighboring gene protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform pseudogene Neighboring gene ninein Neighboring gene uncharacterized LOC102634412 Neighboring gene abhydrolase domain containing 12B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Hippo, organism-specific biosystem (from REACTOME)
    Signaling by Hippo, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hippo signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
hippo signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
intestinal epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
keratinocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein stabilization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of stem cell maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
intracellular IGI
Inferred from Genetic Interaction
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
protein salvador homolog 1
Names
protein salvador homolog 1
45 kDa WW domain protein
WW domain-containing protein 3
WW domain-containing protein 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022028.2NP_071311.1  protein salvador homolog 1

    See proteins identical to NP_071311.1

    Status: PROVISIONAL

    Source sequence(s)
    AC166827
    Consensus CDS
    CCDS25956.1
    UniProtKB/Swiss-Prot
    Q8VEB2
    Related
    ENSMUSP00000021467, ENSMUST00000021467
    Conserved Domains (1) summary
    cd00201
    Location:203233
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000078.6 

    Range
    69965012..69987002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000034.1 

    Range
    71066736..71086376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)