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LCN2 lipocalin 2 [ Homo sapiens (human) ]

Gene ID: 3934, updated on 6-Jul-2014
Official Symbol
LCN2provided by HGNC
Official Full Name
lipocalin 2provided by HGNC
Primary source
HGNC:6526
Locus tag
RP11-395P17.6
See related
Ensembl:ENSG00000148346; HPRD:02551; MIM:600181; Vega:OTTHUMG00000020734
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
24p3; MSFI; NGAL
See LCN2 in Epigenomics, MapViewer
Location:
9q34
Exon count :
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 9 NC_000009.12 (128149453..128153455)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130911732..130915734)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene prostaglandin E synthase 2 Neighboring gene PTGES2 antisense RNA 1 (head to head) Neighboring gene chromosome 9 open reading frame 16 Neighboring gene CDKN1A interacting zinc finger protein 1 Neighboring gene dynamin 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protease binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
small molecule binding IEA
Inferred from Electronic Annotation
more info
 
transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
cellular response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell projection organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
protein homotrimerization IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to herbicide IEA
Inferred from Electronic Annotation
more info
 
response to virus IEA
Inferred from Electronic Annotation
more info
 
siderophore transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
neutrophil gelatinase-associated lipocalin
Names
neutrophil gelatinase-associated lipocalin
p25
lipocalin-2
oncogene 24p3
siderocalin LCN2
migration-stimulating factor inhibitor
25 kDa alpha-2-microglobulin-related subunit of MMP-9

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005564.3NP_005555.2  neutrophil gelatinase-associated lipocalin precursor

    See proteins identical to NP_005555.2

    Status: VALIDATED

    Source sequence(s)
    BC033089, BM977724, BP272828
    Consensus CDS
    CCDS6892.1
    UniProtKB/Swiss-Prot
    P80188
    Related
    ENSP00000277480, OTTHUMP00000022238, ENST00000277480, OTTHUMT00000054373
    Conserved Domains (1) summary
    pfam00061
    Location:49193
    Blast Score: 246
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000009.12 

    Range
    128149453..128153455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000141.1 

    Range
    100525402..100529404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 

    Range
    131062742..131066744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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